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Anti-STAT6 Antibody (5D324)
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Catalog No. TMAY-02527
Alias STAT6C, STAT6B, signal transducer and activator of transcription 6, interleukin-4 induced, IL-4-STAT, D12S1644
Anti-STAT6 Antibody (5D324) is a Mouse antibody targeting STAT6. Anti-STAT6 Antibody (5D324) can be used in FCM.
Anti-STAT6 Antibody (5D324)
Anti-STAT6 Antibody (5D324)
😃Good
Catalog No. TMAY-02527Alias STAT6C, STAT6B, signal transducer and activator of transcription 6, interleukin-4 induced, IL-4-STAT, D12S1644
Anti-STAT6 Antibody (5D324) is a Mouse antibody targeting STAT6. Anti-STAT6 Antibody (5D324) can be used in FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: FCM Reactivity: Human |
| Alias | STAT6C, STAT6B, signal transducer and activator of transcription 6, interleukin-4 induced, IL-4-STAT, D12S1644 |
| Ig Type | Mouse IgG1 |
| Clone | 5D324 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human Stat6 expression on HT-29 cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), stained with purified anti-Human Stat6, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | FCM |
| Recommended Dose | FCM: 1:25-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human STAT6 (rh STAT6; TMPY-02603; P42226-1; Met1-Trp847). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that is activated by interleukin-4 (IL-4)-induced tyrosine phosphorylation and mediates most of the IL-4-induced gene expression. STAT6 plays a central role in exerting interleukin-4 (IL-4) mediated biological responses and is found to induce the expression of BCL2L1/BCL-XL, which is responsible for the anti-apoptotic activity of IL4. Transcriptional activation by STAT6 requires the interaction with coactivators like p300 and the CREB-binding protein (CBP). NF-κB and tyrosine-phosphorylated Stat6 can directly bind each other in vitro and in vivo, which suggests that the direct interaction between Stat6 and NF-κB may provide a basis for synergistic activation of transcription by IL-4 and activators of NF-κB. |
| Conjucates | Unconjugated |
| Others Formats | FITC/PE |
| Antibody Types Available | 3 |
| Immunogen | Recombinant Protein: Human STAT6 protein (TMPY-02603) |
| Antigen Species | Human |
| Biology Area | Apoptosis Transcription Factors and Regulators |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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