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1-Phenylpyrrole

Name: 1-Phenylpyrrole
Brand: TargetMol
SKU: T20373
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20373Cas No. 635-90-5

Alias NSC-16581, NSC16581, NSC 16581

1-Phenylpyrrole (NSC-16581) is an inhibitor of CYP450 dependant monooxygenase activity in microsomes from rat liver.

1-Phenylpyrrole

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Purity: 99.75%

Catalog No. T20373Alias NSC-16581, NSC16581, NSC 16581Cas No. 635-90-5

1-Phenylpyrrole (NSC-16581) is an inhibitor of CYP450 dependant monooxygenase activity in microsomes from rat liver.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
200 mg	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.75%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

1-Phenylpyrrole AI Summary

1-Phenylpyrrole shows bioactivity by binding to FK506 binding protein (FKBP) with a dissociation constant (Kd) greater than 10,000,000 nM. This compound has also been evaluated for its enzymatic activity in rat liver microsomes exposed to beta-naphthoflavone at different concentrations. The Michaelis-Menten constant (Km) values are 28,400 nM, 41,200 nM, and 64,300 nM for exposures at 50 μM, 100 μM, and 150 μM respectively. The maximum rate constant (Vmax) values are 819 pM min^-1 mg^-1, 760 pM min^-1 mg^-1, and 669 pM min^-1 mg^-1 for exposures at 50 μM, 100 μM, and 150 μM respectively. Additionally, the inhibition constant (Ki) was measured at 27,000 nM and the alpha-rate constant (Alpha Ki) at 0.00043 M in liver microsomes from beta-naphthoflavone-exposed rats. These results suggest that 1-Phenylpyrrole interacts with the enzyme involved in 7-ethoxycoumarin deethylation within rat liver microsomes, exhibiting varying levels of inhibition and activity based on beta-naphthoflavone concentration..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1-Phenylpyrrole (NSC-16581) is an inhibitor of CYP450 dependant monooxygenase activity in microsomes from rat liver.
Synonyms	NSC-16581, NSC16581, NSC 16581

Chemical Properties

Molecular Weight	143.19
Formula	C₁₀H₉N
Cas No.	635-90-5
Smiles	c1ccn(c1)-c1ccccc1
Relative Density.	0.97 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (69.84 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (6.98 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.9837 mL	34.9186 mL	69.8373 mL	349.1864 mL
5 mM	1.3967 mL	6.9837 mL	13.9675 mL	69.8373 mL
10 mM	0.6984 mL	3.4919 mL	6.9837 mL	34.9186 mL
20 mM	0.3492 mL	1.7459 mL	3.4919 mL	17.4593 mL
50 mM	0.1397 mL	0.6984 mL	1.3967 mL	6.9837 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc