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Z-AEVD-FMK

Name: Z-AEVD-FMK
Brand: TargetMol
SKU: T36331
Rating: 4.5 (1 reviews)

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Catalog No. T36331Cas No. 1135688-47-9

Alias Z-Ala-Glu-Val-Asp-Fluoromethyl Ketone

Z-AEVD-FMK (Z-Ala-Glu-Val-Asp-Fluoromethyl Ketone) is a degradable ADC linker and caspase-10 inhibitor, reducing TNF-α/butyrate-induced apoptosis, and inhibiting Gal-9-induced apoptosis.

Z-AEVD-FMK

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Catalog No. T36331Alias Z-Ala-Glu-Val-Asp-Fluoromethyl KetoneCas No. 1135688-47-9

Z-AEVD-FMK (Z-Ala-Glu-Val-Asp-Fluoromethyl Ketone) is a degradable ADC linker and caspase-10 inhibitor, reducing TNF-α/butyrate-induced apoptosis, and inhibiting Gal-9-induced apoptosis.

Pack Size	Price	USA Warehouse	Global Warehouse
500 μg	$246	35 days	35 days
1 mg	$468	35 days	35 days
5 mg	$1,980	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	Z-AEVD-FMK (Z-Ala-Glu-Val-Asp-Fluoromethyl Ketone) is a degradable ADC linker and caspase-10 inhibitor, reducing TNF-α/butyrate-induced apoptosis, and inhibiting Gal-9-induced apoptosis.
In vitro	Z-AEVD-FMK (10 μM) inhibited anti-FAS Ab and TNF-α induced apoptosis. [1]
Synonyms	Z-Ala-Glu-Val-Asp-Fluoromethyl Ketone

Chemical Properties

Molecular Weight	610.63
Formula	C₂₈H₃₉FN₄O₁₀
Cas No.	1135688-47-9
Smiles	[C@H](C(N[C@H](C(N[C@@H](CC(OC)=O)C(CF)=O)=O)C(C)C)=O)(NC([C@@H](NC(OCC1=CC=CC=C1)=O)C)=O)CCC(OC)=O
Sequence	Cbz-Ala-Glu(OMe)-Val-Asp(OMe)-CH2F
Sequence Short	AXVX

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (163.77 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6377 mL	8.1883 mL	16.3765 mL	81.8826 mL
5 mM	0.3275 mL	1.6377 mL	3.2753 mL	16.3765 mL
10 mM	0.1638 mL	0.8188 mL	1.6377 mL	8.1883 mL
20 mM	0.0819 mL	0.4094 mL	0.8188 mL	4.0941 mL
50 mM	0.0328 mL	0.1638 mL	0.3275 mL	1.6377 mL
100 mM	0.0164 mL	0.0819 mL	0.1638 mL	0.8188 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc