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GSK2018682

Name: GSK2018682
Brand: TargetMol
SKU: T7360
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7360Cas No. 1034688-30-6

GSK2018682 is an agonist of sphingosine-1-phosphate receptor (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively).

GSK2018682

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Purity: 99.04%

Catalog No. T7360Cas No. 1034688-30-6

GSK2018682 is an agonist of sphingosine-1-phosphate receptor (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively).

Pack Size	Price	Availability
2 mg	$30	In Stock
5 mg	$47	In Stock
10 mg	$80	In Stock
25 mg	$156	In Stock
50 mg	$289	In Stock
100 mg	$428	In Stock
1 mL x 10 mM (in DMSO)	$52	In Stock

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Batch Information

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Purity:99.04%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

GSK2018682 is an agonist of sphingosine-1-phosphate receptor (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively).

Chemical Properties

Molecular Weight	440.88
Formula	C₂₂H₂₁ClN₄O₄
Cas No.	1034688-30-6
Smiles	CC(C)Oc1ncc(cc1Cl)-c1nc(no1)-c1cccc2n(CCCC(O)=O)ccc12
Relative Density.	1.41 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (283.52 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2682 mL	11.3410 mL	22.6819 mL	113.4095 mL
5 mM	0.4536 mL	2.2682 mL	4.5364 mL	22.6819 mL
10 mM	0.2268 mL	1.1341 mL	2.2682 mL	11.3410 mL
20 mM	0.1134 mL	0.5670 mL	1.1341 mL	5.6705 mL
50 mM	0.0454 mL	0.2268 mL	0.4536 mL	2.2682 mL
100 mM	0.0227 mL	0.1134 mL	0.2268 mL	1.1341 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc