MALT1-IN-13

Name: MALT1-IN-13
Brand: TargetMol
SKU: T209402
Rating: 4.5 (1 reviews)

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Catalog No. T209402

MALT1-IN-13 (compound 10m) is an inhibitor of the mucosa-associated lymphoid tissue lymphoma translocation protein (MALT1), forming a covalent and irreversible bond with the MALT1 protease, thereby inhibiting its activity with an IC50 of 1.7 μM. It suppresses the proliferation of ABC-DLBCL and induces apoptosis in ABC-DLBCL HBL1 cells. Additionally, MALT1-IN-13 regulates the mTOR and PI3K-Akt pathways.

MALT1-IN-13

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Catalog No. T209402

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Product Introduction

Bioactivity

Description	MALT1-IN-13 (compound 10m) is an inhibitor of the mucosa-associated lymphoid tissue lymphoma translocation protein (MALT1), forming a covalent and irreversible bond with the MALT1 protease, thereby inhibiting its activity with an IC50 of 1.7 μM. It suppresses the proliferation of ABC-DLBCL and induces apoptosis in ABC-DLBCL HBL1 cells. Additionally, MALT1-IN-13 regulates the mTOR and PI3K-Akt pathways.
In vitro	MALT1-IN-13 (0-10 μM) induces apoptosis in HBL1 cells and inhibits the proliferation of ABC-DLBCL HBL1, TMD8, and GCB-DLBCL OCI-LY1 cells, with GI50 values of 1.5, 0.7, and >25 μM, respectively. It downregulates the expression of the MALT1 and NF-kB pathways, while upregulating the mTOR and PI3K-Akt pathways, exerting antitumor effects in HBL1 cells.
In vivo	MALT1-IN-13 (25 mg/kg, administered intraperitoneally for 12-14 days) demonstrates tumor-specific activity against MALT1 protease, effectively inhibiting tumor growth in HBL1/TMD8 xenograft NCG mice.

Chemical Properties

Formula

C₂₀H₁₅BrClN₃O₃S₂

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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