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MitoBloCK-10

Name: MitoBloCK-10
Brand: TargetMol
SKU: T8741
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T8741Cas No. 394694-98-5

Alias 3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)m

MitoBloCK-10 (3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)m) inhibits Tim44 binding to the precursor and to Hsp70.MitoBloCK-10 is the first small molecule modulator to attenuate protein-associated motor (PAM) complex activity.

MitoBloCK-10

🥰Excellent

Purity: 99.51%

Catalog No. T8741Alias 3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)mCas No. 394694-98-5

Pack Size	Price	Availability
500 μg	$40	In Stock
1 mg	$64	In Stock
5 mg	$155	In Stock
10 mg	$228	In Stock
25 mg	$388	In Stock
50 mg	$568	In Stock
100 mg	$812	In Stock
200 mg	$1,090	In Stock
1 mL x 10 mM (in DMSO)	$146	In Stock

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Batch Information

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Purity:99.51%

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Bioactivity

Description	MitoBloCK-10 (3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)m) inhibits Tim44 binding to the precursor and to Hsp70.MitoBloCK-10 is the first small molecule modulator to attenuate protein-associated motor (PAM) complex activity.
Synonyms	3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)m

Chemical Properties

Molecular Weight	293.27
Formula	C₁₂H₈FN₃O₃S
Cas No.	394694-98-5
Smiles	[O-][N+](=O)c1ccc(\C=N\NC(=O)c2cccc(F)c2)s1
Relative Density.	1.47 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (34.1 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4098 mL	17.0491 mL	34.0983 mL	170.4914 mL
5 mM	0.6820 mL	3.4098 mL	6.8197 mL	34.0983 mL
10 mM	0.3410 mL	1.7049 mL	3.4098 mL	17.0491 mL
20 mM	0.1705 mL	0.8525 mL	1.7049 mL	8.5246 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc