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IDO5L
🥰Excellent
Catalog No. T2647Cas No. 914471-09-3
Alias INCB14943, INCB024360 analogue
IDO5L (INCB024360 analogue) is an effective IDO1 inhibitor(IC50=10 nM).
IDO5L
🥰Excellent
Purity: 99.75%
Catalog No. T2647Alias INCB14943, INCB024360 analogueCas No. 914471-09-3
IDO5L (INCB024360 analogue) is an effective IDO1 inhibitor(IC50=10 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $43 | In Stock | |
| 25 mg | $78 | In Stock | |
| 50 mg | $126 | In Stock | |
| 100 mg | $197 | In Stock | |
| 200 mg | $338 | In Stock | |
| 500 mg | $531 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $30 | In Stock |
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Purity:99.75%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | IDO5L (INCB024360 analogue) is an effective IDO1 inhibitor(IC50=10 nM). |
| Targets&IC50 | IDO1:10 nM |
| In vitro | In an immunologically active mouse model, INCB024360 effectively inhibited tumor growth. Similarly, in mice bearing GM-CSF-secreting B16 tumors, INCB024360 (75 mg/kg b.i.d) demonstrated dose-dependent tumor growth suppression. |
| In vivo | INCB024360 significantly inhibits IDO1 in HeLa cells (IC50 = 19 nM) and promotes differentiation in CD4+ T cells, CD8+ T cells, and NK cells. |
| Alias | INCB14943, INCB024360 analogue |
| Molecular Weight | 271.64 |
| Formula | C9H7ClFN5O2 |
| Cas No. | 914471-09-3 |
| Smiles | Nc1nonc1\C(Nc1ccc(F)c(Cl)c1)=N/O |
| Relative Density. | 1.78 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 27.2 mg/mL (100.13 mM), Sonication is recommended. DMSO: 50 mg/mL (184.07 mM)  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL (18.41 mM) Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
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Sci Citations
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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