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IDO5L

Name: IDO5L
Brand: TargetMol
SKU: T2647
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2647Cas No. 914471-09-3

Alias INCB14943, INCB024360 analogue

IDO5L (INCB024360 analogue) is an effective IDO1 inhibitor(IC50=10 nM).

IDO5L

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Purity: 99.75%

Catalog No. T2647Alias INCB14943, INCB024360 analogueCas No. 914471-09-3

IDO5L (INCB024360 analogue) is an effective IDO1 inhibitor(IC50=10 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$43	In Stock	In Stock
25 mg	$78	In Stock	In Stock
50 mg	$126	In Stock	In Stock
100 mg	$197	In Stock	In Stock
200 mg	$338	In Stock	In Stock
500 mg	$531	-	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.75%

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	IDO5L (INCB024360 analogue) is an effective IDO1 inhibitor(IC50=10 nM).
Targets&IC50	IDO1:10 nM
In vitro	In an immunologically active mouse model, INCB024360 effectively inhibited tumor growth. Similarly, in mice bearing GM-CSF-secreting B16 tumors, INCB024360 (75 mg/kg b.i.d) demonstrated dose-dependent tumor growth suppression.
In vivo	INCB024360 significantly inhibits IDO1 in HeLa cells (IC50 = 19 nM) and promotes differentiation in CD4+ T cells, CD8+ T cells, and NK cells.
Synonyms	INCB14943, INCB024360 analogue

Chemical Properties

Molecular Weight	271.64
Formula	C₉H₇ClFN₅O₂
Cas No.	914471-09-3
Smiles	Nc1nonc1\C(Nc1ccc(F)c(Cl)c1)=N/O
Relative Density.	1.78 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 27.2 mg/mL (100.13 mM), Sonication is recommended.

DMSO: 50 mg/mL (184.07 mM)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL (18.41 mM)

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6813 mL	18.4067 mL	36.8134 mL	184.0671 mL
5 mM	0.7363 mL	3.6813 mL	7.3627 mL	36.8134 mL
10 mM	0.3681 mL	1.8407 mL	3.6813 mL	18.4067 mL
20 mM	0.1841 mL	0.9203 mL	1.8407 mL	9.2034 mL
50 mM	0.0736 mL	0.3681 mL	0.7363 mL	3.6813 mL
100 mM	0.0368 mL	0.1841 mL	0.3681 mL	1.8407 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc