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Anti-CD36 Antibody
(Synonyms: Ona36) Copy Product Info
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Synonyms: Ona36
Catalog No. T9901A-1456 Copy Product Info
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Anti-CD36 Antibody is a humanized monoclonal antibody targeting CD36 (Fatty Acid Translocase/FAT). CD36 is a multi-ligand scavenger receptor widely expressed on monocytes/macrophages, platelets, endothelial cells, and adipocytes, facilitating the uptake of long-chain fatty acids (LCFA) and the binding of oxidized low-density lipoproteins (oxLDL). By specifically binding to CD36, this antibody blocks fatty acid transport or inhibits oxLDL-induced foam cell formation, making it a valuable tool for research in metabolic disorders (e.g., atherosclerosis, diabetes) and cancer lipid metabolism.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $222 | Inquiry | Inquiry | |
| 5 mg | $622 | Inquiry | Inquiry | |
| 10 mg | $998 | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Antibody Information
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| Description | Anti-CD36 Antibody is a humanized monoclonal antibody targeting CD36 (Fatty Acid Translocase/FAT). CD36 is a multi-ligand scavenger receptor widely expressed on monocytes/macrophages, platelets, endothelial cells, and adipocytes, facilitating the uptake of long-chain fatty acids (LCFA) and the binding of oxidized low-density lipoproteins (oxLDL). By specifically binding to CD36, this antibody blocks fatty acid transport or inhibits oxLDL-induced foam cell formation, making it a valuable tool for research in metabolic disorders (e.g., atherosclerosis, diabetes) and cancer lipid metabolism. |
| In vitro | Anti-CD36 Antibody effectively blocks the uptake of fatty acids (e.g., palmitate) and oxidized LDL in CD36-expressing tumor cells. In co-culture assays, it inhibits the metabolic adaptation of regulatory T cells (Tregs) and boosts the effector function of CD8+ T cells by disrupting lipid uptake [1][2]. |
| In vivo | In orthotopic mouse models of human oral cancer and melanoma, systemic administration of neutralizing Anti-CD36 Antibody almost completely inhibits the initiation of metastasis without affecting primary tumor growth significantly. The treatment targets metastasis-initiating cells and modulates the lipid metabolic environment of the tumor [1]. |
| Synonyms | Ona36 |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | CD36 |
| Isotype | IgG1 |
| Storage | Store at low temperature Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Anti-CD36 Antibody chemical structure | Anti-CD36 Antibody in vivo | Anti-CD36 Antibody in vitro
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