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Anti-CD36 Antibody
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Catalog No. T9901A-1456
Alias Ona36
Anti-CD36 Antibody is a humanized monoclonal antibody targeting CD36 (Fatty Acid Translocase/FAT). CD36 is a multi-ligand scavenger receptor widely expressed on monocytes/macrophages, platelets, endothelial cells, and adipocytes, facilitating the uptake of long-chain fatty acids (LCFA) and the binding of oxidized low-density lipoproteins (oxLDL). By specifically binding to CD36, this antibody blocks fatty acid transport or inhibits oxLDL-induced foam cell formation, making it a valuable tool for research in metabolic disorders (e.g., atherosclerosis, diabetes) and cancer lipid metabolism.
Anti-CD36 Antibody
Anti-CD36 Antibody
Copy Product Info🥰Excellent
Catalog No. T9901A-1456Alias Ona36
Anti-CD36 Antibody is a humanized monoclonal antibody targeting CD36 (Fatty Acid Translocase/FAT). CD36 is a multi-ligand scavenger receptor widely expressed on monocytes/macrophages, platelets, endothelial cells, and adipocytes, facilitating the uptake of long-chain fatty acids (LCFA) and the binding of oxidized low-density lipoproteins (oxLDL). By specifically binding to CD36, this antibody blocks fatty acid transport or inhibits oxLDL-induced foam cell formation, making it a valuable tool for research in metabolic disorders (e.g., atherosclerosis, diabetes) and cancer lipid metabolism.
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| Description | Anti-CD36 Antibody is a humanized monoclonal antibody targeting CD36 (Fatty Acid Translocase/FAT). CD36 is a multi-ligand scavenger receptor widely expressed on monocytes/macrophages, platelets, endothelial cells, and adipocytes, facilitating the uptake of long-chain fatty acids (LCFA) and the binding of oxidized low-density lipoproteins (oxLDL). By specifically binding to CD36, this antibody blocks fatty acid transport or inhibits oxLDL-induced foam cell formation, making it a valuable tool for research in metabolic disorders (e.g., atherosclerosis, diabetes) and cancer lipid metabolism. |
| In vitro | Anti-CD36 Antibody effectively blocks the uptake of fatty acids (e.g., palmitate) and oxidized LDL in CD36-expressing tumor cells. In co-culture assays, it inhibits the metabolic adaptation of regulatory T cells (Tregs) and boosts the effector function of CD8+ T cells by disrupting lipid uptake [1][2]. |
| In vivo | In orthotopic mouse models of human oral cancer and melanoma, systemic administration of neutralizing Anti-CD36 Antibody almost completely inhibits the initiation of metastasis without affecting primary tumor growth significantly. The treatment targets metastasis-initiating cells and modulates the lipid metabolic environment of the tumor [1]. |
| Synonyms | Ona36 |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | CD36 |
| Isotype | IgG1 |
| Storage | store at low temperature | -20°C for 2 years, 4°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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