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Emprumapimod

Name: Emprumapimod
Brand: TargetMol
SKU: T63067
Price: 263 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T63067Cas No. 765914-60-1

Alias PF-07265803, ARRY-371797

Emprumapimod (PF-07265803) is an orally active and specific inhibitor of mitogen-activated protein kinase p38α MAPK, inhibits LPS-induced production of IL-6, and can be used to study dilated cardiomyopathy induced by the LMNA gene.

Emprumapimod

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Purity: 99.21%

Catalog No. T63067Alias PF-07265803, ARRY-371797Cas No. 765914-60-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$263	In Stock	In Stock
5 mg	$538	In Stock	In Stock
10 mg	$859	In Stock	In Stock
25 mg	$1,280	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.21%

Appearance:Solid

Color:White to Yellow

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Emprumapimod (PF-07265803) is an orally active and specific inhibitor of mitogen-activated protein kinase p38α MAPK, inhibits LPS-induced production of IL-6, and can be used to study dilated cardiomyopathy induced by the LMNA gene.
In vivo	In LmnaH222P/H222P mice, Emprumapimod (30 mg/kg; administered orally by gavage; starting at 16 weeks of age and continuing until 20 weeks of age) significantly increased left ventricular end-diastolic diameter (LVEDD) and left ventricular end-systolic diameter (LVESD), while reducing FS, a parameter directly proportional to the left ventricular ejection fraction[1].
Synonyms	PF-07265803, ARRY-371797

Chemical Properties

Molecular Weight	473.52
Formula	C₂₄H₂₉F₂N₅O₃
Cas No.	765914-60-1
Smiles	C(C(C)C)N1C=2C(=CC(OC3=C(F)C=C(F)C=C3)=C(C(N[C@@H](CCN(C)C)C(N)=O)=O)C2)C=N1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (168.95 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.97 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1118 mL	10.5592 mL	21.1184 mL	105.5922 mL
5 mM	0.4224 mL	2.1118 mL	4.2237 mL	21.1184 mL
10 mM	0.2112 mL	1.0559 mL	2.1118 mL	10.5592 mL
20 mM	0.1056 mL	0.5280 mL	1.0559 mL	5.2796 mL
50 mM	0.0422 mL	0.2112 mL	0.4224 mL	2.1118 mL
100 mM	0.0211 mL	0.1056 mL	0.2112 mL	1.0559 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc