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Anti-IL-8/CXCL8 Antibody (5K777)

😃Good
Catalog No. TMAY-00250
Alias NAP-1, NAP1, NAF, MONAP, MDNCF, LYNAP, LUCT, LECT, Interleukin-8, IL-8, IL8, GCP-1, GCP1, chemokine (C-X-C motif) ligand 8

Anti-IL-8/CXCL8 Antibody (5K777) is a Mouse antibody targeting IL-8/CXCL8. Anti-IL-8/CXCL8 Antibody (5K777) can be used in ELISA,ELISA(Det).

Anti-IL-8/CXCL8 Antibody (5K777)

Anti-IL-8/CXCL8 Antibody (5K777)

😃Good
Catalog No. TMAY-00250Alias NAP-1, NAP1, NAF, MONAP, MDNCF, LYNAP, LUCT, LECT, Interleukin-8, IL-8, IL8, GCP-1, GCP1, chemokine (C-X-C motif) ligand 8
Anti-IL-8/CXCL8 Antibody (5K777) is a Mouse antibody targeting IL-8/CXCL8. Anti-IL-8/CXCL8 Antibody (5K777) can be used in ELISA,ELISA(Det).
Pack SizePriceAvailabilityQuantity
20 μL$92 7-10 days
100 μL$269 7-10 days
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Product Introduction

Bioactivity
Description
Anti-IL-8/CXCL8 Antibody (5K777) is a Mouse antibody targeting IL-8/CXCL8. Anti-IL-8/CXCL8 Antibody (5K777) can be used in ELISA,ELISA(Det).
AliasNAP-1, NAP1, NAF, MONAP, MDNCF, LYNAP, LUCT, LECT, Interleukin-8, IL-8, IL8, GCP-1, GCP1, chemokine (C-X-C motif) ligand 8
Ig Type
Monoclonal Mouse IgG1
Clone
5K777
Reactivity
Human
Application
ELISA,ELISA(Det)
Recommended Dose
ELISA: 1:1000-1:2000; ELISA(Det): 1:1000-1:10000
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionThis antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL-8/Interleukin-8/CXCL8 (rh IL-8/Interleukin-8/CXCL8; TMPY-04726; NP_000575.1; Ser28-Ser99). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundInterleukin 8 (IL-8), also known as CXCL8, which is a chemokine with a defining CXC amino acid motif that was initially characterized for its leukocyte chemotactic activity, is now known to possess tumorigenic and proangiogenic properties as well. This chemokine is secreted by a variety of cell types including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, and various tumor cell lines in response to inflammatory stimuli (IL1, TNF, LPS, etc). In human gliomas, IL-8 is expressed and secreted at high levels both in vitro and in vivo, and recent experiments suggest it is critical to glial tumor neovascularity and progression. Levels of IL-8 correlate with histologic grade in glial neoplasms, and the most malignant form, glioblastoma, shows the highest expression in pseudopalisading cells around necrosis, suggesting that hypoxia/anoxia may stimulate expression. Interleukin (IL)-8/CXCL8 is a potent neutrophil chemotactic factor. Accumulating evidence has demonstrated that various types of cells can produce a large amount of IL-8/CXCL8 in response to a wide variety of stimuli, including proinflammatory cytokines, microbes and their products, and environmental changes such as hypoxia, reperfusion, and hyperoxia. Numerous observations have established IL-8/CXCL8 as a key mediator in neutrophil-mediated acute inflammation due to its potent actions on neutrophils. However, several lines of evidence indicate that IL-8/CXCL8 has a wide range of actions on various types of cells, including lymphocytes, monocytes, endothelial cells, and fibroblasts, besides neutrophils. The discovery of these biological functions suggests that IL-8/CXCL8 has crucial roles in various pathological conditions such as chronic inflammation and cancer. IL-8 has been associated with tumor angiogenesis, metastasis, and poor prognosis in breast cancer. IL-8 may present a novel therapeutic target for estrogen driven breast carcinogenesis and tumor progression.
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
Biotin/HRP
Antibody Types Available
3
Antigen Details
Immunogen
Recombinant Human IL-8/Interleukin-8/CXCL8 Protein (TMPY-04726)
Antigen Species
Human
Biology Area
Neuroinflammation
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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