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SJB2-043
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Catalog No. T7678Cas No. 63388-44-3
SJB2-043, an inhibitor of USP1-UAF1, has an IC50 of 544 nM.
SJB2-043
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Purity: 98.44%
Catalog No. T7678Cas No. 63388-44-3
SJB2-043, an inhibitor of USP1-UAF1, has an IC50 of 544 nM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $30 | In Stock | In Stock | |
| 10 mg | $48 | In Stock | In Stock | |
| 25 mg | $107 | In Stock | In Stock | |
| 50 mg | $173 | In Stock | In Stock | |
| 100 mg | $273 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $31 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.44%
Appearance:Solid
Color:Yellow
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Product Introduction
SJB2-043 AI Summary
SJB2-043 inhibits the USP1 enzyme with an IC50 value of 544.0 nM and demonstrates antiviral activity by reducing SARS-CoV-2 induced cytotoxicity in VERO-6 cells at 10 µM after 48 hours of exposure to 0.01 MOI of the virus, with a 3.45% inhibition observed. This compound also inhibits the SARS-CoV-2 3CL-Pro protease with an inhibition percentage of -17.95% at 20 µM and the SARS-CoV-2 papain-like protease with an IC50 of 560.0 nM. Additionally, SJB2-043 shows complete inhibition of N-terminal His-6 tagged OTUB1 at 2.5 µM in a fluorescence-based plate reader method. It exhibits cytotoxic activity against human HepG2 cells with an IC50 value of 2600.0 nM as assessed by the CellTiter-Glo luminescent cell viability assay..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | SJB2-043, an inhibitor of USP1-UAF1, has an IC50 of 544 nM. |
| Targets&IC50 | USP1/UAF1:544 nM |
| Molecular Weight | 275.26 |
| Formula | C17H9NO3 |
| Cas No. | 63388-44-3 |
| Smiles | O=C1c2nc(oc2C(=O)c2ccccc12)-c1ccccc1 |
| Relative Density. | 1.373 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 3.33 mg/mL (12.1 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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