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Saccharin 1-methylimidazole

Name: Saccharin 1-methylimidazole
Brand: TargetMol
SKU: T6974
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6974Cas No. 482333-74-4

Alias SMI, Saccharin 1-methylimidazole (SMI)

Saccharin 1-methylimidazole (SMI) is a general-purpose activator used for DNA and RNA synthesis.

Saccharin 1-methylimidazole

🥰Excellent

Purity: 98.21%

Catalog No. T6974Alias SMI, Saccharin 1-methylimidazole (SMI)Cas No. 482333-74-4

Saccharin 1-methylimidazole (SMI) is a general-purpose activator used for DNA and RNA synthesis.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$34	In Stock	In Stock
50 mg	$51	In Stock	In Stock
100 mg	$83	In Stock	In Stock
200 mg	$109	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:98.21%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Saccharin 1-methylimidazole (SMI) is a general-purpose activator used for DNA and RNA synthesis.
In vitro	Exposure to various concentrations of distinct promoters, including phenobarbital and the calcium and sodium salts of saccharin (22, 23, 25, 29, 38), induces calcium-deprived T51B cells to commence DNA synthesis as swiftly and as efficiently, or nearly as efficiently, as when the extracellular calcium concentration is increased to 1.25 mM.
Synonyms	SMI, Saccharin 1-methylimidazole (SMI)

Chemical Properties

Molecular Weight	265.29
Formula	C₇H₅NO₃S·C₄H₆N₂
Cas No.	482333-74-4
Smiles	Cn1ccnc1.O=C1NS(=O)(=O)c2ccccc12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 6 mg/mL (22.62 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.77 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7695 mL	18.8473 mL	37.6946 mL	188.4730 mL
5 mM	0.7539 mL	3.7695 mL	7.5389 mL	37.6946 mL
10 mM	0.3769 mL	1.8847 mL	3.7695 mL	18.8473 mL
20 mM	0.1885 mL	0.9424 mL	1.8847 mL	9.4236 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc