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Recilisib

🥰Excellent
Catalog No. T13862Cas No. 334969-03-8
Alias ON 01210, Ex-RAD

Recilisib (ON 01210) is a radioprotectant that activates AKT and PI3K activities in cells.

Recilisib
Other Forms of Recilisib:
Recilisib sodiumT13862L922139-31-9
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Recilisib

🥰Excellent
Purity: 98.96%
Catalog No. T13862Alias ON 01210, Ex-RADCas No. 334969-03-8
Recilisib (ON 01210) is a radioprotectant that activates AKT and PI3K activities in cells.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$38In StockIn Stock
2 mg$54In StockIn Stock
5 mg$89In StockIn Stock
10 mg$122In StockIn Stock
25 mg$197In StockIn Stock
50 mg$328In StockIn Stock
100 mg$529In StockIn Stock
200 mg$753-In Stock
1 mL x 10 mM (in DMSO)$107In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.96%
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COA HNMR HPLC LCMS

Product Introduction

Bioactivity
Description
Recilisib (ON 01210) is a radioprotectant that activates AKT and PI3K activities in cells.
In vitro
Recilisib Sodium increases PI3K activity in HFL-1 cells and murine bone marrow cells in response to radiation exposure. Recilisib Sodium treatment in combination with radiation alters the MAPK signaling pathway.
In vivo
the rate of recovery and differentiation of primitive bone marrow myeloid progenitor cells in mice significantly increased by Recilisib Sodium. Recilisib Sodium in combination with radiation reduces CFU numbers in mice, but the Recilisib Sodium-treated mice consistently retain a capability to form differentiated colonies. Recilisib Sodium treated mice have a progenitor cell population that is never completely depleted by radiation exposure.
SynonymsON 01210, Ex-RAD
Chemical Properties
Molecular Weight336.79
FormulaC16H13ClO4S
Cas No.334969-03-8
SmilesOC(=O)c1ccc(\C=C\S(=O)(=O)Cc2ccc(Cl)cc2)cc1
Relative Density.1.423 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (148.46 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Corn Oil: 2.5 mg/mL (7.42 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9692 mL14.8460 mL29.6921 mL148.4605 mL
5 mM0.5938 mL2.9692 mL5.9384 mL29.6921 mL
10 mM0.2969 mL1.4846 mL2.9692 mL14.8460 mL
20 mM0.1485 mL0.7423 mL1.4846 mL7.4230 mL
50 mM0.0594 mL0.2969 mL0.5938 mL2.9692 mL
100 mM0.0297 mL0.1485 mL0.2969 mL1.4846 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

RecilisibProtein kinase BPKBPI3KPhosphoinositide 3-kinaseON-01210ON01210InhibitorinhibitAkt
Related Tags: buy Recilisib | purchase Recilisib | Recilisib cost | order Recilisib | Recilisib chemical structure | Recilisib in vivo | Recilisib in vitro | Recilisib formula | Recilisib molecular weight
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