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Recilisib

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Catalog No. T13862Cas No. 334969-03-8
Alias ON 01210, Ex-RAD

Recilisib (ON 01210) is a radioprotectant that activates AKT and PI3K activities in cells.

Recilisib

Recilisib

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Hot
Purity: 98.96%
Catalog No. T13862Alias ON 01210, Ex-RADCas No. 334969-03-8
Recilisib (ON 01210) is a radioprotectant that activates AKT and PI3K activities in cells.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$38In StockIn Stock
2 mg$54In StockIn Stock
5 mg$89In StockIn Stock
10 mg$122In StockIn Stock
25 mg$197In StockIn Stock
50 mg$328In StockIn Stock
100 mg$529In StockIn Stock
200 mg$753-In Stock
1 mL x 10 mM (in DMSO)$107In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:98.96%
Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
Recilisib (ON 01210) is a radioprotectant that activates AKT and PI3K activities in cells.
In vitro
Recilisib Sodium increases PI3K activity in HFL-1 cells and murine bone marrow cells in response to radiation exposure. Recilisib Sodium treatment in combination with radiation alters the MAPK signaling pathway.
In vivo
the rate of recovery and differentiation of primitive bone marrow myeloid progenitor cells in mice significantly increased by Recilisib Sodium. Recilisib Sodium in combination with radiation reduces CFU numbers in mice, but the Recilisib Sodium-treated mice consistently retain a capability to form differentiated colonies. Recilisib Sodium treated mice have a progenitor cell population that is never completely depleted by radiation exposure.
SynonymsON 01210, Ex-RAD
Chemical Properties
Molecular Weight336.79
FormulaC16H13ClO4S
Cas No.334969-03-8
SmilesOC(=O)c1ccc(\C=C\S(=O)(=O)Cc2ccc(Cl)cc2)cc1
Relative Density.1.423 g/cm3 (Predicted)
Storage & Solubility Information
StorageIn solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (148.46 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Corn Oil: 2.5 mg/mL (7.42 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9692 mL14.8460 mL29.6921 mL148.4605 mL
5 mM0.5938 mL2.9692 mL5.9384 mL29.6921 mL
10 mM0.2969 mL1.4846 mL2.9692 mL14.8460 mL
20 mM0.1485 mL0.7423 mL1.4846 mL7.4230 mL
50 mM0.0594 mL0.2969 mL0.5938 mL2.9692 mL
100 mM0.0297 mL0.1485 mL0.2969 mL1.4846 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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