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LMD-009

Name: LMD-009
Brand: TargetMol
SKU: T11862
Price: 199 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11862Cas No. 950195-51-4

Alias LMD009

LMD-009 is a non-peptide, selective CCR8 agonist that mediates chemotaxis, inositol phosphate accumulation, and calcium release, with an EC50 of 11–87 nM.

LMD-009

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Catalog No. T11862Alias LMD009Cas No. 950195-51-4

LMD-009 is a non-peptide, selective CCR8 agonist that mediates chemotaxis, inositol phosphate accumulation, and calcium release, with an EC50 of 11–87 nM.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$199	-	In Stock

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Product Introduction

Bioactivity

Description	LMD-009 is a non-peptide, selective CCR8 agonist that mediates chemotaxis, inositol phosphate accumulation, and calcium release, with an EC50 of 11–87 nM.
Targets&IC50	CCR8:11-87 nM (EC50)
In vitro	Methods: COS-7 cells were treated with LMD-009 (0-20 nM, 90 minutes) and cell viability was measured. Results: LMD-009 stimulated inositol phosphate accumulation in COS-7 cells expressing the human CCR8 receptor with an EC50 value of 11 nM. It did not inhibit any other human chemokine receptors. Methods: Chinese hamster ovary cells were treated with LMD-009 (0-100 nM, 1 hour) and cell viability was measured. Results: The EC50 value of LMD-009 for regulating calcium release in Chinese hamster ovary cells was 87 nM. [1]
Synonyms	LMD009

Chemical Properties

Molecular Weight	471.59
Formula	C₂₉H₃₃N₃O₃
Cas No.	950195-51-4
Smiles	O=C1NCN(CCC=2C=CC=CC2)C13CCN(CC=4C=CC=C(OC=5C=CC=CC5OC)C4)CC3
Relative Density.	1.24 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (424.1 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (10.6 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1205 mL	10.6024 mL	21.2049 mL	106.0243 mL
5 mM	0.4241 mL	2.1205 mL	4.2410 mL	21.2049 mL
10 mM	0.2120 mL	1.0602 mL	2.1205 mL	10.6024 mL
20 mM	0.1060 mL	0.5301 mL	1.0602 mL	5.3012 mL
50 mM	0.0424 mL	0.2120 mL	0.4241 mL	2.1205 mL
100 mM	0.0212 mL	0.1060 mL	0.2120 mL	1.0602 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc