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Pramipexole dihydrochloride hydrate
🥰Excellent
Catalog No. T6951Cas No. 191217-81-9
Alias Pramipexole 2HCl Monohydrate, Mirapex
Pramipexole dihydrochloride hydrate (Mirapex) is the hydrochloride salt of pramipexole, a benzothiazole derivative. As a nonergot dopamine agonist, pramipexole binds to D2 and D3 dopamine receptors in the striatum and substantia nigra of the brain.
Pramipexole dihydrochloride hydrate
🥰Excellent
Purity: 99.68%
Catalog No. T6951Alias Pramipexole 2HCl Monohydrate, MirapexCas No. 191217-81-9
Pramipexole dihydrochloride hydrate (Mirapex) is the hydrochloride salt of pramipexole, a benzothiazole derivative. As a nonergot dopamine agonist, pramipexole binds to D2 and D3 dopamine receptors in the striatum and substantia nigra of the brain.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $39 | In Stock | |
| 25 mg | $68 | In Stock | |
| 50 mg | $122 | In Stock | |
| 100 mg | $178 | In Stock | |
| 200 mg | $268 | In Stock | |
| 500 mg | $453 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $39 | In Stock |
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Purity:99.68%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Pramipexole dihydrochloride hydrate (Mirapex) is the hydrochloride salt of pramipexole, a benzothiazole derivative. As a nonergot dopamine agonist, pramipexole binds to D2 and D3 dopamine receptors in the striatum and substantia nigra of the brain. |
| Targets&IC50 | D3 receptor:0.5 nM (Ki), D4 receptor:1.3 nM (Ki), D2 receptor:3.9 nM (Ki), D2 receptor:2.2 nM (Ki) |
| In vitro | Pramipexole (4-100 mM) significantly attenuated DA- or L-DOPA-induced cytotoxicity and apoptosis, an effect that was not inhibited by the D3 receptor antagonist, U-99194 A, or the D2 receptor antagonist, raclopride.Pramipexole also protected MES23.5 cells from hydrogen peroxide-induced cytotoxicity in a dose-dependent manner. cytotoxicity.Pramipexole effectively inhibited melanin formation.Pramipexole was neuroprotective against nigrostriatal dopamine neurons in hypoxic-ischemic and methamphetamine models. When incubated with SH-SY5Y cells and perfused into rat striatum, Pramipexole reduced the level of oxygen radicals produced by methylpyridinium ion (MPP+).Pramipexole also concentration-dependently inhibited the opening of mitochondrial transporter pore induced by calcium, phosphate, or MPP+. Pramipexole dose Pramipexole dose-dependently decreased dopamine metabolite levels, while striatal dopamine levels remained unchanged. |
| In vivo | Pramipexole (4-100 mM) significantly attenuated DA- or L-DOPA-induced cytotoxicity and apoptosis, an effect that was not inhibited by the D3 receptor antagonist, U-99194 A, or the D2 receptor antagonist, raclopride.Pramipexole also protected MES23.5 cells from hydrogen peroxide-induced cytotoxicity in a dose-dependent manner. cytotoxicity.Pramipexole effectively inhibited melanin formation.Pramipexole was neuroprotective against nigrostriatal dopamine neurons in hypoxic-ischemic and methamphetamine models. When incubated with SH-SY5Y cells and perfused into rat striatum, Pramipexole reduced the level of oxygen radicals produced by methylpyridinium ion (MPP+).Pramipexole also concentration-dependently inhibited the opening of mitochondrial transporter pore induced by calcium, phosphate, or MPP+. Pramipexole dose Pramipexole dose-dependently decreased dopamine metabolite levels, while striatal dopamine levels remained unchanged. |
| Synonyms | Pramipexole 2HCl Monohydrate, Mirapex |
| Molecular Weight | 302.26 |
| Formula | C10H17N3S·2HCl·H2O |
| Cas No. | 191217-81-9 |
| Smiles | O.Cl.CCCN[C@H]1CCc2c(C1)sc(N)n2.Cl |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 3.46 mg/mL (11.45 mM), Sonication is recommended.  H2O: 55 mg/mL (181.96 mM), Sonication is recommended. Ethanol: < 1 mg/mL (insoluble or slightly soluble) | ||||||||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.31 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/H2O
H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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