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Pramipexole dihydrochloride hydrate

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Catalog No. T6951Cas No. 191217-81-9
Alias Pramipexole 2HCl Monohydrate, Mirapex

Pramipexole dihydrochloride hydrate (Mirapex) is the hydrochloride salt of pramipexole, a benzothiazole derivative. As a nonergot dopamine agonist, pramipexole binds to D2 and D3 dopamine receptors in the striatum and substantia nigra of the brain.

Pramipexole dihydrochloride hydrate
Other Forms of Pramipexole dihydrochloride hydrate:

Pramipexole dihydrochloride hydrate

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Purity: 99.68%
Catalog No. T6951Alias Pramipexole 2HCl Monohydrate, MirapexCas No. 191217-81-9
Pramipexole dihydrochloride hydrate (Mirapex) is the hydrochloride salt of pramipexole, a benzothiazole derivative. As a nonergot dopamine agonist, pramipexole binds to D2 and D3 dopamine receptors in the striatum and substantia nigra of the brain.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$39In StockIn Stock
25 mg$68In StockIn Stock
50 mg$122In StockIn Stock
100 mg$178In StockIn Stock
200 mg$268In StockIn Stock
500 mg$453In StockIn Stock
1 mL x 10 mM (in DMSO)$39In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.68%
Appearance:Solid
Color:White
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COA HNMR LCMS

Product Introduction

Pramipexole dihydrochloride hydrate AI Summary
Pramipexole dihydrochloride hydrate exhibits antiviral activity against SARS-CoV-2 by inhibiting virus-induced cytotoxicity in both Caco-2 and VERO-6 cells at a concentration of 10 µM after 48 hours, with inhibition rates of 7.29% and -0.01% respectively. Additionally, Pramipexole dihydrochloride hydrate demonstrates a 5.111% inhibition of the SARS-CoV-2 3CL-Pro protease at 20 µM, based on a FRET assay with a peptide substrate..
Note: Summary generated by AI. Data source: ChEMBL
Bioactivity
Description
Pramipexole dihydrochloride hydrate (Mirapex) is the hydrochloride salt of pramipexole, a benzothiazole derivative. As a nonergot dopamine agonist, pramipexole binds to D2 and D3 dopamine receptors in the striatum and substantia nigra of the brain.
Targets&IC50
D4 receptor:1.3 nM (Ki), D3 receptor:0.5 nM (Ki), D2 receptor:3.9 nM (Ki), D2 receptor:2.2 nM (Ki)
In vitro
Pramipexole (4-100 mM) significantly attenuated DA- or L-DOPA-induced cytotoxicity and apoptosis, an effect that was not inhibited by the D3 receptor antagonist, U-99194 A, or the D2 receptor antagonist, raclopride.Pramipexole also protected MES23.5 cells from hydrogen peroxide-induced cytotoxicity in a dose-dependent manner. cytotoxicity.Pramipexole effectively inhibited melanin formation.Pramipexole was neuroprotective against nigrostriatal dopamine neurons in hypoxic-ischemic and methamphetamine models. When incubated with SH-SY5Y cells and perfused into rat striatum, Pramipexole reduced the level of oxygen radicals produced by methylpyridinium ion (MPP+).Pramipexole also concentration-dependently inhibited the opening of mitochondrial transporter pore induced by calcium, phosphate, or MPP+. Pramipexole dose Pramipexole dose-dependently decreased dopamine metabolite levels, while striatal dopamine levels remained unchanged.
In vivo
Pramipexole (4-100 mM) significantly attenuated DA- or L-DOPA-induced cytotoxicity and apoptosis, an effect that was not inhibited by the D3 receptor antagonist, U-99194 A, or the D2 receptor antagonist, raclopride.Pramipexole also protected MES23.5 cells from hydrogen peroxide-induced cytotoxicity in a dose-dependent manner. cytotoxicity.Pramipexole effectively inhibited melanin formation.Pramipexole was neuroprotective against nigrostriatal dopamine neurons in hypoxic-ischemic and methamphetamine models. When incubated with SH-SY5Y cells and perfused into rat striatum, Pramipexole reduced the level of oxygen radicals produced by methylpyridinium ion (MPP+).Pramipexole also concentration-dependently inhibited the opening of mitochondrial transporter pore induced by calcium, phosphate, or MPP+. Pramipexole dose Pramipexole dose-dependently decreased dopamine metabolite levels, while striatal dopamine levels remained unchanged.
SynonymsPramipexole 2HCl Monohydrate, Mirapex
Chemical Properties
Molecular Weight302.26
FormulaC10H17N3S·2HCl·H2O
Cas No.191217-81-9
SmilesNC1=NC2=C(S1)C[C@H](CC2)NCCC.Cl.O.Cl
Relative Density.no data available
Storage & Solubility Information
StorageIn solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 3.46 mg/mL (11.45 mM), Sonication is recommended.
H2O: 55 mg/mL (181.96 mM), Sonication is recommended.
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.31 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM3.3084 mL16.5420 mL33.0841 mL165.4205 mL
5 mM0.6617 mL3.3084 mL6.6168 mL33.0841 mL
10 mM0.3308 mL1.6542 mL3.3084 mL16.5420 mL
H2O
1mg5mg10mg50mg
20 mM0.1654 mL0.8271 mL1.6542 mL8.2710 mL
50 mM0.0662 mL0.3308 mL0.6617 mL3.3084 mL
100 mM0.0331 mL0.1654 mL0.3308 mL1.6542 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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