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MK-0429

Name: MK-0429
Brand: TargetMol
SKU: T16085
Rating: 4.5 (1 reviews)

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Catalog No. T16085Cas No. 227963-15-7

Alias L-000845704

MK-0429 is an orally active, selective, and nonpeptide antagonist of αvβ3 integrin (IC50: 80 nM).

MK-0429

😃Good

Catalog No. T16085Alias L-000845704Cas No. 227963-15-7

MK-0429 is an orally active, selective, and nonpeptide antagonist of αvβ3 integrin (IC50: 80 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$286	7-10 days	7-10 days
5 mg	Inquiry	7-10 days	7-10 days
10 mg	Inquiry	7-10 days	7-10 days
1 mL x 10 mM (in DMSO)	Inquiry	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	MK-0429 is an orally active, selective, and nonpeptide antagonist of αvβ3 integrin (IC50: 80 nM).
Targets&IC50	αvβ3 integrin:80 nM, α5β1:12.2 nM (fibronectin-binding), αvβ5 integrin:0.1 nM (vitronectin-binding), αvβ8 integrin:0.5 nM (LAP-binding), αvβ6 integrin:0.7 nM (LAP-binding), αvβ1 integrin:1.6 nM (fibronectin-binding)
In vivo	MK-0429 is safe and efficacious in obviously reducing melanoma metastasis in the lungs. MK-0429 (100 or 300 mg/kg, p.o., twice daily b.i.d., 2 weeks) decreases metastatic tumor colony formation and area in the lungs [1].
Synonyms	L-000845704

Chemical Properties

Molecular Weight	439.51
Formula	C₂₃H₂₉N₅O₄
Cas No.	227963-15-7
Relative Density.	1.36 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (568.82 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (7.51 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2753 mL	11.3763 mL	22.7526 mL	113.7631 mL
5 mM	0.4551 mL	2.2753 mL	4.5505 mL	22.7526 mL
10 mM	0.2275 mL	1.1376 mL	2.2753 mL	11.3763 mL
20 mM	0.1138 mL	0.5688 mL	1.1376 mL	5.6882 mL
50 mM	0.0455 mL	0.2275 mL	0.4551 mL	2.2753 mL
100 mM	0.0228 mL	0.1138 mL	0.2275 mL	1.1376 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc