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Homo Sildenafil

Name: Homo Sildenafil
Brand: TargetMol
SKU: T8919
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8919Cas No. 642928-07-2

Homo Sildenafil is an analog of Sildenafil, It acts as a phosphodiesterase inhibitor.

Homo Sildenafil

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Purity: 99.88%

Catalog No. T8919Cas No. 642928-07-2

Homo Sildenafil is an analog of Sildenafil, It acts as a phosphodiesterase inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$35	In Stock	In Stock
5 mg	$58	In Stock	In Stock
10 mg	$93	In Stock	In Stock
25 mg	$197	In Stock	In Stock
50 mg	$296	In Stock	In Stock
100 mg	$413	In Stock	In Stock
200 mg	$582	-	In Stock
1 mL x 10 mM (in DMSO)	$71	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.88%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Homo Sildenafil AI Summary

Homo Sildenafil exhibits bioactivity as an inhibitor of both PDE9 and PDE5A1, with IC50 values of 600.0 nM and 8.9 nM, respectively. The inhibition of PDE5A1 was determined using an assay with [3H]cGMP as a substrate over a 30-minute period by SPA..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Homo Sildenafil is an analog of Sildenafil, It acts as a phosphodiesterase inhibitor.

Chemical Properties

Molecular Weight	488.6
Formula	C₂₃H₃₂N₆O₄S
Cas No.	642928-07-2
Smiles	CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(CC)CC1
Relative Density.	1.37g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (51.17 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0467 mL	10.2333 mL	20.4666 mL	102.3332 mL
5 mM	0.4093 mL	2.0467 mL	4.0933 mL	20.4666 mL
10 mM	0.2047 mL	1.0233 mL	2.0467 mL	10.2333 mL
20 mM	0.1023 mL	0.5117 mL	1.0233 mL	5.1167 mL
50 mM	0.0409 mL	0.2047 mL	0.4093 mL	2.0467 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc