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MP-A08

Name: MP-A08
Brand: TargetMol
SKU: T16128
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16128Cas No. 219832-49-2

MP-A08 is a highly selective, ATP-competitive inhibitor of sphingosine kinase (SPHK1) that targets both SphK1 and SphK2 [Ki: 6.9 ± 0.8 μM and 27 ± 3 μM, respectively].

MP-A08

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Purity: 97.44%

Catalog No. T16128Cas No. 219832-49-2

MP-A08 is a highly selective, ATP-competitive inhibitor of sphingosine kinase (SPHK1) that targets both SphK1 and SphK2 [Ki: 6.9 ± 0.8 μM and 27 ± 3 μM, respectively].

Pack Size	Price	Availability
5 mg	$33	In Stock
10 mg	$53	In Stock
25 mg	$103	In Stock
50 mg	$193	In Stock
100 mg	$343	In Stock
200 mg	$479	In Stock

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Purity:97.44%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	MP-A08 is a highly selective, ATP-competitive inhibitor of sphingosine kinase (SPHK1) that targets both SphK1 and SphK2 [Ki: 6.9 ± 0.8 μM and 27 ± 3 μM, respectively].
In vitro	MP-A08 inhibit SphK2, cause a decrease in EC barrier integrity in vitro in both cell type. MP-A08 blocks pro-proliferative signaling pathways causes mitochondrial-associated apoptosis in an SK-dependent manner. It also reduces the growth of human lung adenocarcinoma tumours in a mouse xenograft model by both inducing tumour cell apoptosis and inhibiting tumour angiogenesis [2]
In vivo	MP-A08 inhibits the growth of human lung tumour xenografts in mice.

Chemical Properties

Molecular Weight	519.64
Formula	C₂₇H₂₅N₃O₄S₂
Cas No.	219832-49-2
Smiles	Cc1ccc(cc1)S(=O)(=O)Nc1ccccc1\C=N\c1ccccc1NS(=O)(=O)c1ccc(C)cc1
Relative Density.	1.28 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: insoluble

DMSO: 55 mg/mL (105.84 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.85 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9244 mL	9.6220 mL	19.2441 mL	96.2205 mL
5 mM	0.3849 mL	1.9244 mL	3.8488 mL	19.2441 mL
10 mM	0.1924 mL	0.9622 mL	1.9244 mL	9.6220 mL
20 mM	0.0962 mL	0.4811 mL	0.9622 mL	4.8110 mL
50 mM	0.0385 mL	0.1924 mL	0.3849 mL	1.9244 mL
100 mM	0.0192 mL	0.0962 mL	0.1924 mL	0.9622 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc