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Simepdekinra (Synonyms: LY-4100511, LY4100511, DC-853, DC853)

Name: Simepdekinra
Brand: TargetMol
SKU: T210537
Price: 597 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T210537 Copy Product Info

Purity: 99.96%

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Simepdekinra (Compound 221) is a potent IL-17A modulator with IC₅₀ values ≤10 nM for IL-17A/A HEK-Blue cells and 10–100 nM for IL-17A/F HEK-Blue cells, suitable for studying psoriasis, ankylosing spondylitis, and psoriatic arthritis.

Simepdekinra

Copy Product Info

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Catalog No. T210537

Synonyms LY-4100511, LY4100511, DC-853, DC853

Cas No. 2978700-29-5

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Pack Size	Price	USA Stock	Global Stock
1 mg	$597	-	In Stock
5 mg	$1,490	-	In Stock
10 mg	$2,370	-	In Stock
25 mg	$3,970	-	In Stock
50 mg	$5,490	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.96%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Simepdekinra (Compound 221) is a potent IL-17A modulator with IC₅₀ values ≤10 nM for IL-17A/A HEK-Blue cells and 10–100 nM for IL-17A/F HEK-Blue cells, suitable for studying psoriasis, ankylosing spondylitis, and psoriatic arthritis.
Targets&IC50	IL-17A:≤10 nM, IL-17F:10-100 nM
Synonyms	LY-4100511, LY4100511, DC-853, DC853

Chemical Properties

Molecular Weight	667.81
Formula	C₃₅H₅₀FN₇O₅
Cas No.	2978700-29-5
Smiles	[C@H]([C@H](NC(=O)C=1N(CC)N=CC1)C(NC2=C(F)C=C([C@@H]([C@H](C(=O)N3C[C@@H](C)N(C)CC3)NC([C@@H](OC)C)=O)C)C=C2)=O)(C4CC4)C5CC5
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice.

Solubility Information

DMSO: 200 mg/mL (299.49 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 20 mg/mL (29.95 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4974 mL	7.4872 mL	14.9743 mL	74.8716 mL
5 mM	0.2995 mL	1.4974 mL	2.9949 mL	14.9743 mL
10 mM	0.1497 mL	0.7487 mL	1.4974 mL	7.4872 mL
20 mM	0.0749 mL	0.3744 mL	0.7487 mL	3.7436 mL
50 mM	0.0299 mL	0.1497 mL	0.2995 mL	1.4974 mL
100 mM	0.0150 mL	0.0749 mL	0.1497 mL	0.7487 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Citations

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc