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GSK137647A

Name: GSK137647A
Brand: TargetMol
SKU: T3171
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3171Cas No. 349085-82-1

Alias GSK 137647

GSK137647A (GSK 137647) is a selective agonist of FFA4.

GSK137647A

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Purity: 99.42%

Catalog No. T3171Alias GSK 137647Cas No. 349085-82-1

GSK137647A (GSK 137647) is a selective agonist of FFA4.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$47	In Stock	In Stock
10 mg	$77	In Stock	In Stock
25 mg	$157	In Stock	In Stock
50 mg	$257	In Stock	In Stock
100 mg	$447	In Stock	In Stock
200 mg	$646	In Stock	In Stock
500 mg	$987	-	In Stock
1 mL x 10 mM (in DMSO)	$52	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.42%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	GSK137647A (GSK 137647) is a selective agonist of FFA4.
Kinase Assay	HDAC-inhibitory activity: For the enzyme assay, 10 μL of [3H]acetyl-labeled histones (25,000 cpm/10 μg) are added to 90 μL of the HDAC enzyme fraction extracted from 293T cells overexpressing HDAC1 or HDAC2 in the presence of increasing concentrations of Romidepsin, and the mixture is incubated at 37 °C for 15 minutes. The enzyme reaction is linear for at least 1 hour. The reaction is stopped by the addition of 10 μL of concentrated HCl. The released [3H]acetic acid is extracted with 1 mL of ethylacetate, and 0.9 mL of the solvent layer is taken into 5 mL of aqueous counting scintillant II solution for determination of radioactivity. The IC50 values are determined from at least three independent dose-response curves.
Synonyms	GSK 137647

Chemical Properties

Molecular Weight	305.39
Formula	C₁₆H₁₉NO₃S
Cas No.	349085-82-1
Smiles	COc1ccc(cc1)S(=O)(=O)Nc1c(C)cc(C)cc1C
Relative Density.	1.214 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (163.73 mM), Sonication is recommended.

H2O: < 0.06 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (8.19 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2745 mL	16.3725 mL	32.7450 mL	163.7251 mL
5 mM	0.6549 mL	3.2745 mL	6.5490 mL	32.7450 mL
10 mM	0.3275 mL	1.6373 mL	3.2745 mL	16.3725 mL
20 mM	0.1637 mL	0.8186 mL	1.6373 mL	8.1863 mL
50 mM	0.0655 mL	0.3275 mL	0.6549 mL	3.2745 mL
100 mM	0.0327 mL	0.1637 mL	0.3275 mL	1.6373 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc