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AMX5160
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Catalog No. T207216Cas No. 2639293-95-9
AMX5160 (36) is an orally active BTK inhibitor with an IC50 value of 0.98 nM for BTKC481S. It is utilized in research pertaining to multiple sclerosis and other autoimmune diseases.
AMX5160
😃Good
Catalog No. T207216Cas No. 2639293-95-9
AMX5160 (36) is an orally active BTK inhibitor with an IC50 value of 0.98 nM for BTKC481S. It is utilized in research pertaining to multiple sclerosis and other autoimmune diseases.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | AMX5160 (36) is an orally active BTK inhibitor with an IC50 value of 0.98 nM for BTKC481S. It is utilized in research pertaining to multiple sclerosis and other autoimmune diseases. |
| In vitro | AMX5160 exhibits an IC50 value of 93.2 nM in TMD8 cells and 85.85 nM in Ba/F3-BTK-C481S cells. |
| In vivo | AMX5160 (36; NIH/3T3-FL-BTK-C481S xenograft BALB/c nude mouse model; 10, 25, 75 mg/kg; oral; twice daily) significantly inhibits tumor growth in a dose-dependent manner. Tumor growth inhibition rates (TGI) are 58%, 63%, and 82% at doses of 10, 25, and 75 mg/kg, respectively. AMX5160 (36) is well-tolerated in mice. |
| Molecular Weight | 502.99 |
| Formula | C28H27ClN4O3 |
| Cas No. | 2639293-95-9 |
| Smiles | C(=O)(C=1C2=C(N[C@H]3CC[C@@H](NC(C)=O)CC3)C=CN=C2NC1)C4=C(Cl)C=C(OC5=CC=CC=C5)C=C4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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