Shopping Cart

Your shopping cart is currently empty

PD 90780

Name: PD 90780
Brand: TargetMol
SKU: T12384
Price: 51 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T12384Cas No. 77422-99-2

PD 90780 is a non-peptide antagonist of nerve growth factor (NGF) that interacts with NGF and prevents it from binding to p75NTR, inhibiting the NGF-p75NTR interaction with IC50s of 23.1 and 1.8 µM in PC12 cells and PC12nnr5 cells, respectively.

PD 90780

🥰Excellent

Purity: 99.22%

Catalog No. T12384Cas No. 77422-99-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$51	In Stock	In Stock
5 mg	$122	In Stock	In Stock
10 mg	$197	In Stock	In Stock
25 mg	$397	In Stock	In Stock
50 mg	$589	In Stock	In Stock
100 mg	$843	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$133	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.22%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	PD 90780 is a non-peptide antagonist of nerve growth factor (NGF) that interacts with NGF and prevents it from binding to p75NTR, inhibiting the NGF-p75NTR interaction with IC50s of 23.1 and 1.8 µM in PC12 cells and PC12nnr5 cells, respectively.
Targets&IC50	NGF (PC12 nnr5 cells):1.8 µM , NGF (PC12 cells):23.1 µM
In vitro	PD 90780 (0.1-100 μM; 2 h) impacts 125I-BDNF binding to truncated p75NTR, and at 100 μM, it inhibits 125I-NGF cross-linking to p75NTR. At concentrations of 0-300 μM, PD 90780 decreases TrkA phosphorylation resulting from NGF binding, with significant inhibition noted at 300 μM. Additionally, PD 90780 (0.1-100 μM; 2 h) inhibits the NGF-p75NTR interaction with IC50 values of 23.1 µM in PC12 cells and 1.8 µM in PC12nnr5 cells[1].

Chemical Properties

Molecular Weight	362.34
Formula	C₁₉H₁₄N₄O₄
Cas No.	77422-99-2
Smiles	Cn1c2cc(nn2c(=O)c2cc(NC(=O)c3ccccc3)ccc12)C(O)=O
Relative Density.	1.48 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 28.8 mg/mL (79.48 mM), Sonication and heating to 60℃ are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7598 mL	13.7992 mL	27.5984 mL	137.9919 mL
5 mM	0.5520 mL	2.7598 mL	5.5197 mL	27.5984 mL
10 mM	0.2760 mL	1.3799 mL	2.7598 mL	13.7992 mL
20 mM	0.1380 mL	0.6900 mL	1.3799 mL	6.8996 mL
50 mM	0.0552 mL	0.2760 mL	0.5520 mL	2.7598 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc