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Minodronic acid

Catalog No. T8436 CAS 180064-38-4

Synonyms: Phosphonicacid,(1-hydroxy-2-imidazo(1,2-a)pyridin-3-ylethylidene)bis-, ONO-5920, YM-529

Minodronic acid(YM-529) is a P2X2/3 receptor antagonist with anticancer activity, directly or indirectly inhibiting the proliferation of cancer cells and inducing apoptosis. Minodronic acid has been shown to inhibit the metastasis of various types of cancer cells.Minodronic-acid has been used in the study of osteoporosis.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Minodronic acid, CAS 180064-38-4

Pack Size	Availability	Price/USD
5 mg	In stock	$ 30.00
10 mg	In stock	$ 42.00
25 mg	In stock	$ 70.00
50 mg	In stock	$ 122.00
100 mg	In stock	$ 198.00
500 mg	In stock	$ 513.00

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Purity: 98.02%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	Phosphonicacid,(1-hydroxy-2-imidazo(1,2-a)pyridin-3-ylethylidene)bis-, ONO-5920, YM-529
Molecular Weight	322.15
Formula	C9H12N2O7P2
CAS No.	180064-38-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: < 1 mg/mL (insoluble or slightly soluble)

H2O: 4 mg/mL (12.42 mM), Sonication is recommended.

References and Literature

1. Sato K, et al. A third-generation bisphosphonate, minodronic acid (YM529), successfully prevented the growth of bladder cancer in vitro and in vivo. Br J Cancer. 2006 Nov 20;95(10):1354-61. 2. Tanaka M, et al. Minodronic acid induces morphological changes in osteoclasts at bone resorption sites and reaches a level required for antagonism of purinergic P2X2/3 receptors. J Bone Miner Metab. 2018 Jan;36(1):54-63.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library Membrane Protein-targeted Compound Library Drug Repurposing Compound Library Bioactive Compound Library Approved Drug Library FDA-Approved & Pharmacopeia Drug Library Bioactive Compounds Library Max

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Minodronic acid 180064-38-4 Apoptosis Membrane transporter/Ion channel Neuroscience P2X Receptor Phosphonicacid,(1-hydroxy-2-imidazo(1,2-a)pyridin-3-ylethylidene)bis- ONO-5920 YM-529 ONO 5920 ONO5920 YM529 YM 529 inhibitor inhibit

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