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Minodronic acid

Name: Minodronic acid
Brand: TargetMol
SKU: T8436
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8436Cas No. 180064-38-4

Alias YM-529, Phosphonicacid,(1-hydroxy-2-imidazo(1,2-a)pyridin-3-ylethylidene)bis-, ONO-5920

Minodronic acid(YM-529) is a P2X2/3 receptor antagonist with anticancer activity, directly or indirectly inhibiting the proliferation of cancer cells and inducing apoptosis. Minodronic acid has been shown to inhibit the metastasis of various types of cancer cells.Minodronic-acid has been used in the study of osteoporosis.

Minodronic acid

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Purity: 99.39%

Catalog No. T8436Alias YM-529, Phosphonicacid,(1-hydroxy-2-imidazo(1,2-a)pyridin-3-ylethylidene)bis-, ONO-5920Cas No. 180064-38-4

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$40	-	In Stock
25 mg	$64	-	In Stock
50 mg	$93	-	In Stock
100 mg	$129	-	In Stock
500 mg	$326	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.39%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Minodronic acid AI Summary

Minodronic acid exhibits a variety of bioactivities across different biological systems. It shows inhibitory activity in the stimulation of TNF-alpha release in gamma-delta T cells with IC50 values ranging from 4100.0 nM to 8000.0 nM. Minodronic acid is also active in inhibiting the growth of Toxoplasma gondii in HFF cells with an IC50 value of 1880.0 nM. It demonstrates antibacterial activity against Escherichia coli W3110, presenting an inhibition zone of 10.0 mm and inhibiting Escherichia coli FPPS with an IC50 value of 1100.0 nM, although it does not affect Escherichia coli pTMV19. In enzyme inhibition assays, Minodronic acid shows potent inhibition of geranylgeranyl diphosphate synthase (GGPPS) in various organisms and binds to yeast and human GGPPS enzymes with low Ki values. It inhibits human FPPS with an IC50 value as low as 1.9 nM and exhibits weaker inhibition against GGPPS (IC50 = 670.0 nM). It also displays cytotoxic effects on mouse J774 cells (IC50 = 3000.0 nM) and inhibits RGGT-mediated prenylation in these cells at 3.0 uM but demonstrates less effect on recombinant RGGT. Moreover, the compound inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) with an IC50 of 11885.6 nM. Additionally, Minodronic acid reduces hypercalcemia in subcutaneously dosed rats with an MED of 0.03 mg/kg. In antiviral studies, Minodronic acid inhibits SARS-CoV-2 induced cytotoxicity in both Caco-2 and VERO-6 cells, although with modest inhibition rates. It also inhibits the SARS-CoV-2 3CL-Pro protease by 22.38% at 20 µM. In enzymatic assays, the compound inhibits FDPS with an IC50 value of 3.0 nM and demonstrates HDAC6 inhibition activity, reducing activity by 33.1% using a commercial peptide substrate and by 5.04% with a custom substrate. Overall, Minodronic acid is a multifaceted compound with potential applications in modulating immune responses, antibacterial and antiviral therapies, enzyme inhibition, and potentially as a tool in cancer therapy..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Minodronic acid(YM-529) is a P2X2/3 receptor antagonist with anticancer activity, directly or indirectly inhibiting the proliferation of cancer cells and inducing apoptosis. Minodronic acid has been shown to inhibit the metastasis of various types of cancer cells.Minodronic-acid has been used in the study of osteoporosis.
Synonyms	YM-529, Phosphonicacid,(1-hydroxy-2-imidazo(1,2-a)pyridin-3-ylethylidene)bis-, ONO-5920

Chemical Properties

Molecular Weight	322.15
Formula	C₉H₁₂N₂O₇P₂
Cas No.	180064-38-4
Smiles	OC(Cc1cnc2ccccn12)(P(O)(O)=O)P(O)(O)=O
Relative Density.	1.973 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: < 1 mg/mL (insoluble or slightly soluble)

H2O: 4 mg/mL (12.42 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	3.1041 mL	15.5207 mL	31.0414 mL	155.2072 mL
5 mM	0.6208 mL	3.1041 mL	6.2083 mL	31.0414 mL
10 mM	0.3104 mL	1.5521 mL	3.1041 mL	15.5207 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc