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LM-1685

Name: LM-1685
Brand: TargetMol
SKU: T32824
Price: 147 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T32824Cas No. 416901-58-1

Alias LM1685, LM 1685

LM-1685 is a potent and selective inhibitor of COX-2 IN human monocytes and whole blood with IC50 of 0.65µM and IC50 = 4.3μM, respectively, and is a potential compound for the treatment of inflammation.

LM-1685

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Purity: 99.75%

Catalog No. T32824Alias LM1685, LM 1685Cas No. 416901-58-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$147	In Stock	In Stock
5 mg	$348	In Stock	In Stock
10 mg	$475	In Stock	In Stock
25 mg	$667	In Stock	In Stock
50 mg	$826	In Stock	In Stock
100 mg	$1,050	In Stock	In Stock
200 mg	$1,370	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.75%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	LM-1685 is a potent and selective inhibitor of COX-2 IN human monocytes and whole blood with IC50 of 0.65µM and IC50 = 4.3μM, respectively, and is a potential compound for the treatment of inflammation.
Targets&IC50	COX-2 (human monocytes):0.65 µM, COX-2 (whole blood):4.3μM
In vitro	We found that continuous exposure to cytostatic doses of CAI and LM-1685, a celecoxib analog, reduced the proliferation and survival of seven human cancer cell lines by at least one log (P < or = 0.001) over either agent alone. The supra-additive antiproliferative effects occurred throughout a range of LM-1685 doses (5-25 micromol/L) and paralleled a decrease in COX-2 activity as measured by prostaglandin E2 production. In these cells, treatment with LM-1685/CAI suppressed the extracellular signal-regulated kinase pathway within the first hour but ultimately results in high, sustained activation of ERK over a 9-day period (P = 0.0005). [1]
Synonyms	LM1685, LM 1685

Chemical Properties

Molecular Weight	377.84
Formula	C₁₈H₁₆ClNO₄S
Cas No.	416901-58-1
Smiles	C(N1C=2C(C=C1C(OC)=O)=CC(S(C)(=O)=O)=CC2)C3=CC=C(Cl)C=C3
Relative Density.	1.35 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (238.2 mM), Sonication is recommended.

Methanol: 0.9 mg/mL (2.38 mM), Sonication is recommended.

Solution Preparation Table

Methanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6466 mL	13.2331 mL	26.4662 mL	132.3311 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.5293 mL	2.6466 mL	5.2932 mL	26.4662 mL
10 mM	0.2647 mL	1.3233 mL	2.6466 mL	13.2331 mL
20 mM	0.1323 mL	0.6617 mL	1.3233 mL	6.6166 mL
50 mM	0.0529 mL	0.2647 mL	0.5293 mL	2.6466 mL
100 mM	0.0265 mL	0.1323 mL	0.2647 mL	1.3233 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc