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HIV-1 inhibitor-41
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Catalog No. T61031
HIV-1 inhibitor-41 (Compound B23) is an orally active non-nucleoside HIV-1 reverse transcriptase inhibitor with EC50 values of 50 nM against the mutant E138K strain and 20.8 nM against HIV-1 WT. HIV-1 inhibitor-41 exhibits low hERG inhibition, no apparent CYP enzymatic inhibition, and no acute toxicity [1].
HIV-1 inhibitor-41
HIV-1 inhibitor-41
😃Good
Catalog No. T61031
HIV-1 inhibitor-41 (Compound B23) is an orally active non-nucleoside HIV-1 reverse transcriptase inhibitor with EC50 values of 50 nM against the mutant E138K strain and 20.8 nM against HIV-1 WT. HIV-1 inhibitor-41 exhibits low hERG inhibition, no apparent CYP enzymatic inhibition, and no acute toxicity [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 10-14 weeks | |
| 50 mg | $1,980 | 10-14 weeks | |
| 100 mg | $2,500 | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | HIV-1 inhibitor-41 (Compound B23) is an orally active non-nucleoside HIV-1 reverse transcriptase inhibitor with EC50 values of 50 nM against the mutant E138K strain and 20.8 nM against HIV-1 WT. HIV-1 inhibitor-41 exhibits low hERG inhibition, no apparent CYP enzymatic inhibition, and no acute toxicity [1]. |
| Targets&IC50 | Y181C:0.75 μM, L100I:1.03 μM, HIV-1 (WT):20.8 nM, Y188L:69.04 μM, E138K:50 nM, K103N:3.39 μM |
| Molecular Weight | 335.37 |
| Formula | C16H15F2N3OS |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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