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Anti-ST2/IL-1 RL1 Polyclonal Antibody
(Synonyms: T1, ST2V, ST2L, ST2, interleukin 1 receptor-like 1, IL33R, IL1RL1, IL‑1 R4, FIT-1, DER4) Copy Product Info
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Synonyms: T1, ST2V, ST2L, ST2, interleukin 1 receptor-like 1, IL33R, IL1RL1, IL‑1 R4, FIT-1, DER4
Catalog No. TMAB-01776 Copy Product Info
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Anti-ST2/IL-1 RL1 Polyclonal Antibody is a Rabbit antibody targeting ST2/IL-1 RL1. Anti-ST2/IL-1 RL1 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB.
Anti-ST2/IL-1 RL1 Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-ST2/IL-1 RL1 Polyclonal Antibody is a Rabbit antibody targeting ST2/IL-1 RL1. Anti-ST2/IL-1 RL1 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB. |
| Synonyms | T1, ST2V, ST2L, ST2, interleukin 1 receptor-like 1, IL33R, IL1RL1, IL‑1 R4, FIT-1, DER4 |
| Ig Type | IgG |
| Reactivity | Human,Mouse |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Isoform C: Cell membrane.Isoform B: Secreted. Cell membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | ST2 is a member of a superfamily containing the Interleukin 1 (IL1) receptor and the Toll-like receptors (TLRs). The TLRs are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. ST2 was originally identified as a protein whose production was stimulated by various proliferation-inducing agents such as PDGF and FGF. More recently, it has been shown to negatively regulate IL1 receptor and Toll-like receptor 4 (TLR4) signaling and to maintain endotoxin tolerance. It has been suggested that the inhibition of TLR4 signaling occurs through the association and sequestering of TLR adaptor molecules such as MyD88 and TIRAP. |
| Immunogen | KLH conjugated synthetic peptide: human ST2 (isoform A,B,C) |
| Antigen Species | Human |
| Gene Name | IL1RL1 |
| Gene ID | |
| Protein Name | Interleukin-1 receptor-like 1 |
| Uniprot ID | |
| Function | Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function. |
| Molecular Weight | Theoretical: 61 kDa. Actual: 61 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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