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NOS1-IN-1

Name: NOS1-IN-1
Brand: TargetMol
SKU: T37696
Price: 106 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T37696Cas No. 357965-99-2

Alias nNOS Inhibitor I

NOS1-IN-1(nNOS Inhibitor I) is a potent, selective and cell permeable nNOS inhibitor (Ki: 120 nM).NOS1-IN-1 has a Ki value of 39 μM for eNOS and 325 μM for iNOS.NOS1-IN-1 can be used for the study of neurological disorders such as cerebral palsy.

NOS1-IN-1

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Purity: 99.20%

Catalog No. T37696Alias nNOS Inhibitor ICas No. 357965-99-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$106	-	In Stock
5 mg	$233	-	In Stock
10 mg	$350	-	In Stock
25 mg	$595	-	In Stock
50 mg	$882	-	In Stock
100 mg	$1,190	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.20%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	NOS1-IN-1(nNOS Inhibitor I) is a potent, selective and cell permeable nNOS inhibitor (Ki: 120 nM).NOS1-IN-1 has a Ki value of 39 μM for eNOS and 325 μM for iNOS.NOS1-IN-1 can be used for the study of neurological disorders such as cerebral palsy.
Targets&IC50	nNOS:120 nM (Ki)
Synonyms	nNOS Inhibitor I

Chemical Properties

Molecular Weight	589.37
Formula	C₁₄H₂₄F₉N₇O₈
Cas No.	357965-99-2
Smiles	OC(C(F)(F)F)=O.NCCNC[C@@H](N)CCCNC(N[N+]([O-])=O)=N.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (76.35 mM), Sonication is recommended.

H2O: 5 mg/mL (8.48 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6967 mL	8.4836 mL	16.9673 mL	84.8364 mL
5 mM	0.3393 mL	1.6967 mL	3.3935 mL	16.9673 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.1697 mL	0.8484 mL	1.6967 mL	8.4836 mL
20 mM	0.0848 mL	0.4242 mL	0.8484 mL	4.2418 mL
50 mM	0.0339 mL	0.1697 mL	0.3393 mL	1.6967 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc