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Protamine sulfate

Catalog No. T41031 CAS 9009-65-8

Protamine sulfate is a polycationic peptide that serves as an antiheparin agent. This compound can neutralize the anticoagulant action of heparin and enhance lipid-mediated gene transfer.

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Protamine sulfate, CAS 9009-65-8

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50 mg	In stock	$ 30.00
100 mg	In stock	$ 39.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Protamine sulfate is a polycationic peptide that serves as an antiheparin agent. This compound can neutralize the anticoagulant action of heparin and enhance lipid-mediated gene transfer.
In vitro	Protamine sulfate, a 5-kDa cationic polypeptide derived from salmon sperm, demonstrates a concentration-dependent, partial, and reversible inhibitory effect on thrombin's ability to convert fibrinogen to fibrin. This compound also binds negatively charged unfractionated heparin (UFH), concurrently downregulating thrombin generation through the inhibition of factor V activation.

Molecular Weight	N/A
CAS No.	9009-65-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 45.0 mg/mL, Sonication is recommended.

References and Literature

1. Ahmed Kouta, et al. Protamine Sulfate Neutralization Profile of Various Dosages of Bovine, Ovine and Porcine UFHs and Their Depolymerized Derivatives in Non-Human Primates. Clin Appl Thromb Hemost. Jan-Dec 2021;27:10760296211005544. 2. F L Sorgi, et al. Protamine sulfate enhances lipid-mediated gene transfer. Gene Ther. 1997 Sep;4(9):961-8. 3. R J Cobel-Geard, et al. Interaction of protamine sulfate with thrombin. Am J Hematol. 1983 May;14(3):227-33. 4. Fionnuala Ni Ainle, et al. Protamine sulfate down-regulates thrombin generation by inhibiting factor V activation. Blood. 2009 Aug 20;114(8):1658-65.

Related Products

Related compounds with same targets

NQ301 Thrombin (MW 37kDa) OM-189 Dabigatran ethyl ester hydrochloride Efegatran sulfate Ozagrel hydrochloride Proflavine Hemisulfate Lusutrombopag

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Keywords

Protamine sulfate 9009-65-8 Proteases/Proteasome Thrombin Protamine Sulfate inhibitor inhibit

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