Shopping Cart
- Remove All
Your shopping cart is currently empty
SAR247799
🥰Excellent
Catalog No. T38716Cas No. 1315311-14-8
Alias SAR 247799, S1P1 agonist 3
SAR247799 (S1P1 agonist 3) is a selective and G-protein-biased S1P1 agonist that activates downstream G-protein signaling pathways more preferentially than β-blocker proteins and internalized signaling pathways, activates S1P 1 on endothelial cells without causing receptor desensitization, and protects the endothelium without affecting lymphocyte populations, and can be used to study type 2 diabetes, endothelial dysfunction and vascular hyperpermeability.
SAR247799
🥰Excellent
Catalog No. T38716Alias SAR 247799, S1P1 agonist 3Cas No. 1315311-14-8
SAR247799 (S1P1 agonist 3) is a selective and G-protein-biased S1P1 agonist that activates downstream G-protein signaling pathways more preferentially than β-blocker proteins and internalized signaling pathways, activates S1P 1 on endothelial cells without causing receptor desensitization, and protects the endothelium without affecting lymphocyte populations, and can be used to study type 2 diabetes, endothelial dysfunction and vascular hyperpermeability.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $1,462 | In Stock |
Bulk & Custom
Add to Cart
Questions
View More
Cited
Select Batch
Contact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | SAR247799 (S1P1 agonist 3) is a selective and G-protein-biased S1P1 agonist that activates downstream G-protein signaling pathways more preferentially than β-blocker proteins and internalized signaling pathways, activates S1P 1 on endothelial cells without causing receptor desensitization, and protects the endothelium without affecting lymphocyte populations, and can be used to study type 2 diabetes, endothelial dysfunction and vascular hyperpermeability. |
| Targets&IC50 | β-arrestin recruitment (S1P1, HEK293 cells):15 nM (EC50), Gi-mediated cAMP (S1P1, HEK293 cells):1.4 nM (EC50) |
| In vitro | SAR247799 is a potent G protein–biased agonist of human S1P1 receptors in HEK293 cells. It showed an EC₅₀ of 1.4 nM in Gi-mediated cAMP inhibition assays, but a much weaker EC₅₀ of 15 nM for β-arrestin recruitment, indicating strong bias toward G protein signaling. In endothelial cells, SAR247799 (1–100 nM) upregulated eNOS and KLF2, promoting vascular protection[1]. |
| In vivo | In Zucker fa/fa rats (a type 2 diabetes model), oral administration of SAR247799 (0.002–0.24 mg/kg daily for 5 weeks) significantly improved arterial compliance, reduced urinary albumin excretion, and increased renal blood flow at low doses (0.007 mg/kg) without causing peripheral lymphopenia. The treatment also increased expression of endothelial genes (eNOS, KLF2), supporting its vascular-protective action via G protein–biased S1P1 activation[1]. |
| Alias | SAR 247799, S1P1 agonist 3 |
| Molecular Weight | 425.82 |
| Formula | C21H16ClN3O5 |
| Cas No. | 1315311-14-8 |
| Smiles | O=C(O)COC=1C(=CC(=CC1C)C2=NC3=CN=C(N=C3O2)OC=4C=CC=C(Cl)C4)C |
| Relative Density. | 1.412 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 20.00 mg/mL (46.97 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||
Sci Citations
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy SAR247799 | purchase SAR247799 | SAR247799 cost | order SAR247799 | SAR247799 chemical structure | SAR247799 in vivo | SAR247799 in vitro | SAR247799 formula | SAR247799 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.