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Amibegron hydrochloride (Synonyms: SR-58611A, SR58611A, SR 58611A)

Name: Amibegron hydrochloride
Brand: TargetMol
SKU: T10302
Price: 97 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T10302 Copy Product Info

Purity: 98.83%

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Amibegron hydrochloride is a selective β3-adrenergic receptor (β3AR) agonist that increases energy expenditure and fat oxidation by activating β3ARs in brown adipose tissue; Amibegron hydrochloride is commonly used in research on metabolic disorders. Amibegron hydrochloride exhibits anxiolytic and antidepressant activity.

Amibegron hydrochloride

Copy Product Info

🥰Excellent

Catalog No. T10302

Synonyms SR-58611A, SR58611A, SR 58611A

Cas No. 121524-09-2

Pack Size	Price	USA Stock	Global Stock
1 mg	$97	-	In Stock
5 mg	$238	-	In Stock
10 mg	$353	-	In Stock
25 mg	$589	-	In Stock
50 mg	$839	-	In Stock
100 mg	$1,130	-	In Stock
1 mL x 10 mM (in DMSO)	$273	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:98.83%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Amibegron hydrochloride is a selective β3-adrenergic receptor (β3AR) agonist that increases energy expenditure and fat oxidation by activating β3ARs in brown adipose tissue; Amibegron hydrochloride is commonly used in research on metabolic disorders. Amibegron hydrochloride exhibits anxiolytic and antidepressant activity.
Targets&IC50	β-adrenoceptor:3.5 nM (EC50), β-adrenoceptor:499 nM
In vitro	Methods: Brain slices from SD rats (P14–P23) containing the prefrontal cortex (PFC) were perfused with 15 μM amibegron hydrochloride in a bath; the maximum effect was reached after approximately 5 minutes. Whole-cell patch-clamp recordings were used to measure AMPA receptor-mediated excitatory postsynaptic currents (AMPAR-EPSCs). Results: Amibegron hydrochloride (15 μM) significantly enhanced the amplitude of AMPAR-EPSCs (by approximately 30%). [1] Methods: Isolated brain slices from adult male Long-Evans rats were perfused with 5 μM amibegron hydrochloride (continuous) while being stimulated with LFS (1 Hz) for 15 minutes. Recordings of field excitatory postsynaptic potentials (fEPSPs) were performed continuously for 30 minutes following LFS. Results: In the presence of amibegron hydrochloride, LFS induced long-term depression of fEPSP. [2]
In vivo	Methods: Adult male Long-Evans rats underwent fear conditioning training. Prior to training, a microinjection of Amibegron hydrochloride (1 µg/0.5 µL per side) was administered bilaterally into the BLA. Fear-potentiated startle responses were assessed 24 hours later. Results: Fear learning was blocked in the Amibegron hydrochloride group compared to the control group. [2]
Synonyms	SR-58611A, SR58611A, SR 58611A

Chemical Properties

Molecular Weight	440.36
Formula	C₂₂H₂₇Cl₂NO₄
Cas No.	121524-09-2
Smiles	N(C[C@H](O)C1=CC(Cl)=CC=C1)[C@@H]2CC=3C(=CC=C(OCC(OCC)=O)C3)CC2.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (181.67 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2709 mL	11.3543 mL	22.7087 mL	113.5435 mL
5 mM	0.4542 mL	2.2709 mL	4.5417 mL	22.7087 mL
10 mM	0.2271 mL	1.1354 mL	2.2709 mL	11.3543 mL
20 mM	0.1135 mL	0.5677 mL	1.1354 mL	5.6772 mL
50 mM	0.0454 mL	0.2271 mL	0.4542 mL	2.2709 mL
100 mM	0.0227 mL	0.1135 mL	0.2271 mL	1.1354 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc