store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
APE1-IN-1 is a potent purine/pyrimidine endonuclease 1 (APE1)-free inhibitor that crosses the blood-brain barrier with potential antitumor activity and potentiates the cytotoxicity of the alkylating agent, methyl methanesulfonate, on cancer cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 62.00 |
Description | APE1-IN-1 is a potent purine/pyrimidine endonuclease 1 (APE1)-free inhibitor that crosses the blood-brain barrier with potential antitumor activity and potentiates the cytotoxicity of the alkylating agent, methyl methanesulfonate, on cancer cells. |
Targets&IC50 | qHTS assay:2 μM, Radiotracer incision assay:12 μM |
In vitro |
In the qHTS assay, APE1-IN-1 (compound 3) displays an IC50 of 2 μM, while in a radiotracer incision assay (RIA), it exhibits an IC50 of 12 μM[1]. In a dose-dependent manner, APE1-IN-1 (at concentrations of 0, 1, 3, 10, 30, or 100 μM for 15 minutes) inhibits AP site incision in HeLa whole cell extracts[1]. Furthermore, APE1-IN-1 (at concentrations ranging from 5 to 30 μM for 24 hours) demonstrates cytotoxic activity against HeLa cells and enhances the activity of methyl methansulfonate and Temozolomide[1]. |
In vivo | Administered at a single dosage of 30 mpk via intraperitoneal injection, APE1-IN-1 demonstrates favorable pharmacokinetic properties[1]. |
Molecular Weight | 371.52 |
Formula | C19H21N3OS2 |
CAS No. | 524708-03-0 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL(26.92 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
APE1-IN-1 524708-03-0 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis inhibitor inhibit