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OICR-0547

Name: OICR-0547
Brand: TargetMol
SKU: T12290
Price: 69 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12290Cas No. 1801873-49-3

Alias OICR0547

OICR-0547 is an inactive derivative of OICR-9429 and is commonly used as a negative control for OICR-9429. OICR-9429 is an inhibitor of the interaction between WDR5 and the mixed leukaemia (MLL) protein.

OICR-0547

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Catalog No. T12290Alias OICR0547Cas No. 1801873-49-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$69	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	OICR-0547 is an inactive derivative of OICR-9429 and is commonly used as a negative control for OICR-9429. OICR-9429 is an inhibitor of the interaction between WDR5 and the mixed leukaemia (MLL) protein.
In vitro	OICR-0547 (0.1-100 μM) was used to treat K562 cells and Cebpap30/p30 cells. OICR-0547 had no effect on the viability of either cell line. [1]
In vivo	OICR-0547 (3 mg/kg, intravenous injection) and (30 mg/kg, intraperitoneal injection) can be used as a negative control model in NOD-SCID mice.[2]
Synonyms	OICR0547

Chemical Properties

Molecular Weight	542.55
Formula	C₂₈H₂₉F₃N₄O₄
Cas No.	1801873-49-3
Smiles	O=C1C=C(C(=CN1)C(=O)NC2=CC(=CC=C2N3CCOCC3)C=4C=CC=C(C4)CN5CCOCC5)C(F)(F)F
Relative Density.	1.358 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 180 mg/mL (331.77 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (7.37 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8431 mL	9.2157 mL	18.4315 mL	92.1574 mL
5 mM	0.3686 mL	1.8431 mL	3.6863 mL	18.4315 mL
10 mM	0.1843 mL	0.9216 mL	1.8431 mL	9.2157 mL
20 mM	0.0922 mL	0.4608 mL	0.9216 mL	4.6079 mL
50 mM	0.0369 mL	0.1843 mL	0.3686 mL	1.8431 mL
100 mM	0.0184 mL	0.0922 mL	0.1843 mL	0.9216 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc