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OICR-0547

Name: OICR-0547
Brand: TargetMol
SKU: T12290
Price: 69 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12290Cas No. 1801873-49-3

Alias OICR0547

OICR-0547 is an inactive derivative of OICR-9429 and is commonly used as a negative control for OICR-9429. OICR-9429 is an inhibitor of the interaction between WDR5 and the mixed leukaemia (MLL) protein.

OICR-0547

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Catalog No. T12290Alias OICR0547Cas No. 1801873-49-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$69	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	OICR-0547 is an inactive derivative of OICR-9429 and is commonly used as a negative control for OICR-9429. OICR-9429 is an inhibitor of the interaction between WDR5 and the mixed leukaemia (MLL) protein.
In vitro	OICR-0547 (0.1-100 μM) was used to treat K562 cells and Cebpap30/p30 cells. OICR-0547 had no effect on the viability of either cell line. [1]
In vivo	OICR-0547 (3 mg/kg, intravenous injection) and (30 mg/kg, intraperitoneal injection) can be used as a negative control model in NOD-SCID mice.[2]
Synonyms	OICR0547

Chemical Properties

Molecular Weight	542.55
Formula	C₂₈H₂₉F₃N₄O₄
Cas No.	1801873-49-3
Smiles	O=C1C=C(C(=CN1)C(=O)NC2=CC(=CC=C2N3CCOCC3)C=4C=CC=C(C4)CN5CCOCC5)C(F)(F)F
Relative Density.	1.358 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 180 mg/mL (331.77 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (7.37 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8431 mL	9.2157 mL	18.4315 mL	92.1574 mL
5 mM	0.3686 mL	1.8431 mL	3.6863 mL	18.4315 mL
10 mM	0.1843 mL	0.9216 mL	1.8431 mL	9.2157 mL
20 mM	0.0922 mL	0.4608 mL	0.9216 mL	4.6079 mL
50 mM	0.0369 mL	0.1843 mL	0.3686 mL	1.8431 mL
100 mM	0.0184 mL	0.0922 mL	0.1843 mL	0.9216 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc