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Ilomastat

Name: Ilomastat
Brand: TargetMol
SKU: T2743
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2743Cas No. 142880-36-2

Alias GM6001, Galardin

Ilomastat (GM6001) (GM6001, Galardin) is a broad spectrum matrix metalloprotease (MMP) inhibitor.

Ilomastat

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Purity: 99.51%

Catalog No. T2743Alias GM6001, GalardinCas No. 142880-36-2

Ilomastat (GM6001) (GM6001, Galardin) is a broad spectrum matrix metalloprotease (MMP) inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$41	In Stock	In Stock
2 mg	$59	In Stock	In Stock
5 mg	$96	In Stock	In Stock
10 mg	$156	In Stock	In Stock
25 mg	$283	In Stock	In Stock
50 mg	$477	-	In Stock
100 mg	$688	-	In Stock
200 mg	$978	-	In Stock
1 mL x 10 mM (in DMSO)	$101	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.51%

Color:White

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COA

Product Introduction

Bioactivity

Description	Ilomastat (GM6001) (GM6001, Galardin) is a broad spectrum matrix metalloprotease (MMP) inhibitor.
Targets&IC50	MMP1:0.4 nM(Ki), MMP26:0.36 nM(Ki), MMP9:0.2 nM(Ki), MMP8:0.1 nM(Ki), Eastase:20 nM (Ki), MMP2:0.5 nM(Ki), MMP3:1.9 nM, Thermolysin:20 nM (Ki)
In vivo	Topical application of GM6001 (400 μg/ml) prevents corneal ulceration after severe alkali injury. [3] In rabbit model after stenting, GM6001 significantly inhibits intimal hyperplasia and intimalcollagen content, and it increases lumen area in stented arteries without effects on proliferation rates. [4]
Kinase Assay	Collagenase assay uses the synthetic thiol ester substrate Ac-Pro-Leu-Gly-SCH(i-Bu)CO-Leu-Gly-OEt at pH 6.5. The collagenase concentration is 1-2 nM, and the substrate concentrations are from 0.1 to 0.7 nM. Km?is found to vary between 1.5 and 4 mM.
Synonyms	GM6001, Galardin

Chemical Properties

Molecular Weight	388.46
Formula	C₂₀H₂₈N₄O₄
Cas No.	142880-36-2
Smiles	CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)CC(=O)NO
Relative Density.	1.228 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from moisture,store under nitrogen | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 83.32 mg/mL (214.49 mM)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (8.5 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5743 mL	12.8713 mL	25.7427 mL	128.7134 mL
5 mM	0.5149 mL	2.5743 mL	5.1485 mL	25.7427 mL
10 mM	0.2574 mL	1.2871 mL	2.5743 mL	12.8713 mL
20 mM	0.1287 mL	0.6436 mL	1.2871 mL	6.4357 mL
50 mM	0.0515 mL	0.2574 mL	0.5149 mL	2.5743 mL
100 mM	0.0257 mL	0.1287 mL	0.2574 mL	1.2871 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc