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NPB

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Catalog No. T12249Cas No. 2247491-97-8
Alias Alpha-NPB

NPB (Alpha-NPB) is a potent BAD phosphorylation inhibitor(at Ser99,IC50 of 0.41 μM.)

NPB

NPB

😃Good
Purity: 99.93%
Catalog No. T12249Alias Alpha-NPBCas No. 2247491-97-8
NPB (Alpha-NPB) is a potent BAD phosphorylation inhibitor(at Ser99,IC50 of 0.41 μM.)
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$44In StockIn Stock
5 mg$107In StockIn Stock
10 mg$178In StockIn Stock
25 mg$293In StockIn Stock
50 mg$407In StockIn Stock
100 mg$536In StockIn Stock
200 mg$736-In Stock
1 mL x 10 mM (in DMSO)$119In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.93%
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Product Introduction

Bioactivity
Description
NPB (Alpha-NPB) is a potent BAD phosphorylation inhibitor(at Ser99,IC50 of 0.41 μM.)
Targets&IC50
BAD Ser99:0.41 μM
SynonymsAlpha-NPB
Chemical Properties
Molecular Weight524.48
FormulaC29H31Cl2N3O2
Cas No.2247491-97-8
SmilesOc1ccccc1C(N1CCN(CC1)c1cccc(Cl)c1Cl)c1cccc(c1)C(=O)NC1CCCC1
Relative Density.1.35 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 45 mg/mL (85.8 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9067 mL9.5333 mL19.0665 mL95.3325 mL
5 mM0.3813 mL1.9067 mL3.8133 mL19.0665 mL
10 mM0.1907 mL0.9533 mL1.9067 mL9.5333 mL
20 mM0.0953 mL0.4767 mL0.9533 mL4.7666 mL
50 mM0.0381 mL0.1907 mL0.3813 mL1.9067 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

α-NPBNPBBADa-NPB
Related Tags: buy NPB | purchase NPB | NPB cost | order NPB | NPB chemical structure | NPB formula | NPB molecular weight
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