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Anti-C-MPL Antibody (1H828)
(Synonyms: TPOR, THCYT2, MPLV, MPL proto-oncogene, thrombopoietin receptor, C-MPL, CD110) Copy Product Info
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Synonyms: TPOR, THCYT2, MPLV, MPL proto-oncogene, thrombopoietin receptor, C-MPL, CD110
Catalog No. TMAC-02642 Copy Product Info
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Anti-C-MPL Antibody (1H828) is a Mouse antibody targeting C-MPL. Anti-C-MPL Antibody (1H828) can be used in FCM,WB.
Anti-C-MPL Antibody
(1H828)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 µL | $297 | 7-10 days | 7-10 days | |
| 100 µL | $428 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-C-MPL Antibody (1H828) is a Mouse antibody targeting C-MPL. Anti-C-MPL Antibody (1H828) can be used in FCM,WB. |
| Synonyms | TPOR, THCYT2, MPLV, MPL proto-oncogene, thrombopoietin receptor, C-MPL, CD110 |
| Clone | 1H828 |
| Reactivity | Human |
| Verified Activity | 1. Western blot analysis of MPL on human MPL recombinant protein using anti-MPL antibody at 1/1,000 dilution. 2. Flow cytometric analysis of MOLT4 cells with MPL antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).  , |
| Application | |
| Recommended Dose | WB: 1:500-1000; FCM: 1:100-200 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide. |
| Research Background | Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 71 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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