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Guanosine 5'-diphosphate

Name: Guanosine 5'-diphosphate
Brand: TargetMol
SKU: T7210
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7210Cas No. 146-91-8

Alias GDP

Guanosine 5'-diphosphate (GDP) as Potential Iron Mobilizer, Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway.

Guanosine 5'-diphosphate

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Purity: 99.52%

Catalog No. T7210Alias GDPCas No. 146-91-8

Guanosine 5'-diphosphate (GDP) as Potential Iron Mobilizer, Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$37	In Stock	-
10 mg	$51	In Stock	-
25 mg	$74	In Stock	-
50 mg	$89	In Stock	-
100 mg	$165	In Stock	-
200 mg	$248	In Stock	-
500 mg	$469	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.52%

Appearance:solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Guanosine 5'-diphosphate AI Summary

Guanosine 5'-diphosphate demonstrates a broad spectrum of bioactivities across multiple targets and assays. It inhibits fucosyltransferase enzymes, including Fucosyltransferase 4 alpha 1,3 with an IC50 value of 5000.0 nM, Fucosyltransferase (FucT V) with an IC50 value of 67000.0 nM, and human recombinant alpha1,3-fucosyltransferase 9 with a Ki of 77900.0 nM and an IC50 of 59000.0 nM. Moreover, it inhibits Helicobacter pylori recombinant alpha1,3-fucosyltransferase with an inhibition percentage of up to 75.0%. In addition, it has a binding affinity to Escherichia coli KPR (Kd of 373000.0 nM) and shows an inhibition of 8.5% on Trypanosoma brucei brucei DPMS at 1 mM. In terms of receptor activity, Guanosine 5'-diphosphate acts as an agonist at human recombinant P2Y2, P2Y4, and P2Y6 receptors, with respective EC50 values of 54.0, 90.0, and 45000.0 nM, mediated by PLC and [3H]IP production. It also induces phagocytosis in Wistar rat microglia, showing 49.7% activity at 100 uM over 20 minutes. Furthermore, the compound exhibits bioactivity in several other assays: it enhances SMN2 splice variant expression (potency of 14125.4 nM), inhibits Aldehyde Dehydrogenase 1 (ALDH1A1) with a potency of 2818.4 nM, and inhibits Regulator of G Protein Signaling (RGS) 4 with a potency of 597.3 nM. It also shows binding affinity to Mg2+ ions as determined by 31P NMR analysis with activities of 0.5 and 2.0 equiv, and interacts with various mutants of Rab7 GTPase and wild-type Rab7 with Kd values ranging from 25.83 nM to 109.2 nM, suggesting potential modulatory effects on Rab7 GTPase functions..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Guanosine 5'-diphosphate (GDP) as Potential Iron Mobilizer, Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway.
Synonyms	GDP

Chemical Properties

Molecular Weight	443.2
Formula	C₁₀H₁₅N₅O₁₁P₂
Cas No.	146-91-8
Smiles	O[C@H]1[C@H](N2C3=C(N=C2)C(=O)N=C(N)N3)O[C@H](COP(OP(=O)(O)O)(=O)O)[C@H]1O
Relative Density.	2.63 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 50 mg/mL (112.82 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.2563 mL	11.2816 mL	22.5632 mL	112.8159 mL
5 mM	0.4513 mL	2.2563 mL	4.5126 mL	22.5632 mL
10 mM	0.2256 mL	1.1282 mL	2.2563 mL	11.2816 mL
20 mM	0.1128 mL	0.5641 mL	1.1282 mL	5.6408 mL
50 mM	0.0451 mL	0.2256 mL	0.4513 mL	2.2563 mL
100 mM	0.0226 mL	0.1128 mL	0.2256 mL	1.1282 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc