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IL-6R alpha/CD126 Protein, Human, Recombinant, Biotinylated
(Synonyms: interleukin 6 receptor, IL6RQ, IL-6RA, IL6RA, IL-6R-1, IL-6R, IL6Q, gp80, CD126) Copy Product InfoSynonyms: interleukin 6 receptor, IL6RQ, IL-6RA, IL6RA, IL-6R-1, IL-6R, IL6Q, gp80, CD126
Catalog No. TMPY-05640 Copy Product Info
IL-6R Protein, Human, Recombinant, Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 67.1 kDa and the accession number is A0N0L5.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | $167 | 7-10 days | 7-10 days | |
| 10 µg | $277 | 7-10 days | 7-10 days | |
| 20 µg | $462 | 7-10 days | 7-10 days | |
| 50 µg | $746 | 7-10 days | 7-10 days | |
| 100 µg | $1,230 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Immobilized Human IL-6 at 2 μg/mL (100 μL/well) can bind Human IL-6R (ECD, hFc & AVI Tag), Biotinylated , the EC50 is 300-1200 ng/mL. |
| Description | IL-6R Protein, Human, Recombinant, Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 67.1 kDa and the accession number is A0N0L5. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | Tag Free |
| Accession Number | P08887 |
| Construction | A DNA sequence encoding the human IL6R (NP_000556.1) (Met1-Pro356) was expressed with a c-terminal AVI tagged Fc region of human IgG1 tag at the C-terminus. The expressed protein was biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed. Predicted N terminal: Leu 20 |
| Protein Purity | > 85 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC. |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
| Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
| Synonyms | interleukin 6 receptor, IL6RQ, IL-6RA, IL6RA, IL-6R-1, IL-6R, IL6Q, gp80, CD126 |
| Research Background | Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (SIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a SIL-6R protein can mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signaling. Through this so-called 'trans-signaling' mechanism, IL-6 can stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and SIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Molecular Weight | 67.1 kDa (predicted) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: IL-6R alpha/CD126 Protein, Human, Recombinant, Biotinylated chemical structure | IL-6R alpha/CD126 Protein, Human, Recombinant, Biotinylated molecular weight
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