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BRD 4354 ditrifluoroacetate

Name: BRD 4354 ditrifluoroacetate
Brand: TargetMol
SKU: T10602
Rating: 4.5 (1 reviews)

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Catalog No. T10602

Alias BRD 4354 ditrifluoroacetate (315698-07-8 free base)

BRD 4354 (ditrifluoroacetate) is a moderately potent inhibitor of HDAC5 and HDAC9 with IC50 values of 0.85 μM and 1.88 μM, respectively.

BRD 4354 ditrifluoroacetate

😃Good

Catalog No. T10602Alias BRD 4354 ditrifluoroacetate (315698-07-8 free base)

BRD 4354 (ditrifluoroacetate) is a moderately potent inhibitor of HDAC5 and HDAC9 with IC50 values of 0.85 μM and 1.88 μM, respectively.

Pack Size	Price	Availability
25 mg	$1,520	4-6 weeks
50 mg	$1,980	4-6 weeks
100 mg	$2,500	4-6 weeks

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Product Introduction

Bioactivity

Description	BRD 4354 (ditrifluoroacetate) is a moderately potent inhibitor of HDAC5 and HDAC9 with IC50 values of 0.85 μM and 1.88 μM, respectively.
Targets&IC50	HDAC5:0.85 μM, HDAC9:1.88 μM
Synonyms	BRD 4354 ditrifluoroacetate (315698-07-8 free base)

Chemical Properties

Molecular Weight	610.93
Formula	C₂₅H₂₅ClF₆N₄O₅
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (204.61 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6368 mL	8.1842 mL	16.3685 mL	81.8424 mL
5 mM	0.3274 mL	1.6368 mL	3.2737 mL	16.3685 mL
10 mM	0.1637 mL	0.8184 mL	1.6368 mL	8.1842 mL
20 mM	0.0818 mL	0.4092 mL	0.8184 mL	4.0921 mL
50 mM	0.0327 mL	0.1637 mL	0.3274 mL	1.6368 mL
100 mM	0.0164 mL	0.0818 mL	0.1637 mL	0.8184 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc