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N-piperidine Ibrutinib hydrochloride

🥰Excellent
Catalog No. T12152Cas No. 2231747-18-3

N-piperidine Ibrutinib hydrochloride is a potent BTK inhibitor, a BTK ligand, inhibits WT BTK and C481S BTK, which can be used to synthesize a range of PROTAC molecules.N-piperidine Ibrutinib hydrochloride has potential anticancer N-piperidine Ibrutinib hydrochloride has potential anticancer activity, inhibiting the growth and proliferation of cancer cells.

N-piperidine Ibrutinib hydrochloride
Other Forms of N-piperidine Ibrutinib hydrochloride:
N-piperidine IbrutinibT9408330785-90-5
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N-piperidine Ibrutinib hydrochloride

🥰Excellent
Purity: 98.83%
Catalog No. T12152Cas No. 2231747-18-3
N-piperidine Ibrutinib hydrochloride is a potent BTK inhibitor, a BTK ligand, inhibits WT BTK and C481S BTK, which can be used to synthesize a range of PROTAC molecules.N-piperidine Ibrutinib hydrochloride has potential anticancer N-piperidine Ibrutinib hydrochloride has potential anticancer activity, inhibiting the growth and proliferation of cancer cells.
Pack SizePriceAvailabilityQuantity
1 mg$48In Stock
5 mg$113In Stock
10 mg$183In Stock
25 mg$352In Stock
50 mg$523In Stock
100 mg$757In Stock
1 mL x 10 mM (in DMSO)$39In Stock
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Batch Information

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Purity:98.83%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
N-piperidine Ibrutinib hydrochloride is a potent BTK inhibitor, a BTK ligand, inhibits WT BTK and C481S BTK, which can be used to synthesize a range of PROTAC molecules.N-piperidine Ibrutinib hydrochloride has potential anticancer N-piperidine Ibrutinib hydrochloride has potential anticancer activity, inhibiting the growth and proliferation of cancer cells.
Targets&IC50
BTK (WT):51.0 nM, BTK (C481S):30.7 nM
In vitro
N-piperidine Ibrutinib hydrochloride can be used to synthesize effective PROTAC BTK degraders, such as SJF638, SJF678, and SJF608[2].
Chemical Properties
Molecular Weight422.91
FormulaC22H23ClN6O
Cas No.2231747-18-3
SmilesCl.Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCNCC1
Relative Density.no data available
Storage & Solubility Information
Storagekeep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (189.16 mM), Sonication is recommended.
H2O: 30 mg/mL (70.94 mM), Sonication is recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM2.3646 mL11.8228 mL23.6457 mL118.2285 mL
5 mM0.4729 mL2.3646 mL4.7291 mL23.6457 mL
10 mM0.2365 mL1.1823 mL2.3646 mL11.8228 mL
20 mM0.1182 mL0.5911 mL1.1823 mL5.9114 mL
50 mM0.0473 mL0.2365 mL0.4729 mL2.3646 mL
DMSO
1mg5mg10mg50mg
100 mM0.0236 mL0.1182 mL0.2365 mL1.1823 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

WT BTKN-piperidine Ibrutinib HydrochlorideNpiperidine Ibrutinib hydrochlorideN piperidine Ibrutinib hydrochlorideC481S BTKBTK
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