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Skp2 Inhibitor C1

Name: Skp2 Inhibitor C1
Brand: TargetMol
SKU: T4253
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4253Cas No. 432001-69-9

Alias SKPin C1

Skp2 Inhibitor C1 (SKPin C1)(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation.

Skp2 Inhibitor C1

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Purity: 97.36%

Catalog No. T4253Alias SKPin C1Cas No. 432001-69-9

Skp2 Inhibitor C1 (SKPin C1)(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$31	In Stock	In Stock
5 mg	$50	In Stock	In Stock
10 mg	$82	In Stock	In Stock
25 mg	$176	In Stock	In Stock
50 mg	$293	In Stock	In Stock
100 mg	$429	In Stock	In Stock
200 mg	$597	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$52	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.36%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Skp2 Inhibitor C1 (SKPin C1)(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation.
In vitro	in vitro: T47D cells treated with C1 (5 μM for 16 hours) displayed an increase in G1 phase (p < 0.0001) and a decrease in S phase (p < 0.0001), correlating with p27 protein induction. In contrast, MCF-7 cells responded to C1 with a significant reduction in G1 phase (35%, p < 0.0001) and an increase in G2-M phase (43%, p < 0.0001). This G1 reduction and G2/M arrest is dose dependent on C1 and correlates with increased p27 protein levels.
Kinase Assay	To test enzyme activity of NOS, the lysate from RAW264.7 cells (a protein concentration of 37.5 μg/200 μL) is incubated for 3 h at 37°C with 100 mM of L-arginine in the presence of Esonarimod (KE-298) and the conversion of L-arginine to nitrite is monitored.
Synonyms	SKPin C1

Chemical Properties

Molecular Weight	465.34
Formula	C₁₈H₁₃BrN₂O₄S₂
Cas No.	432001-69-9
Smiles	OC(=O)COc1ccc(Br)cc1\C=C1/SC(=S)N(Cc2cccnc2)C1=O
Relative Density.	1.74 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (107.45 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 2.5 mg/mL (5.37 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1490 mL	10.7448 mL	21.4897 mL	107.4483 mL
5 mM	0.4298 mL	2.1490 mL	4.2979 mL	21.4897 mL
10 mM	0.2149 mL	1.0745 mL	2.1490 mL	10.7448 mL
20 mM	0.1074 mL	0.5372 mL	1.0745 mL	5.3724 mL
50 mM	0.0430 mL	0.2149 mL	0.4298 mL	2.1490 mL
100 mM	0.0215 mL	0.1074 mL	0.2149 mL	1.0745 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc