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Anti-Caveolin-1 Antibody (1D910)

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Catalog No. TMAB-03703

Anti-Caveolin-1 Antibody (1D910) is a Rabbit antibody targeting Caveolin-1. Anti-Caveolin-1 Antibody (1D910) can be used in IHC-P,IHC-Fr,IF.

Anti-Caveolin-1 Antibody (1D910)

Anti-Caveolin-1 Antibody (1D910)

😃Good
Catalog No. TMAB-03703
Anti-Caveolin-1 Antibody (1D910) is a Rabbit antibody targeting Caveolin-1. Anti-Caveolin-1 Antibody (1D910) can be used in IHC-P,IHC-Fr,IF.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 μL$1487-10 days7-10 days
50 μL$2637-10 days7-10 days
100 μL$4737-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-Caveolin-1 Antibody (1D910) is a Rabbit antibody targeting Caveolin-1. Anti-Caveolin-1 Antibody (1D910) can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
Clone
1D910
Reactivity
Human
Application
Recommended Dose
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
Antibody Type
Monoclonal
Host SpeciesRabbit
Subcellular LocalizationGolgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae.
Tissue SpecificityExpressed in muscle and lung, less so in liver, brain and kidney.
ConstructionRecombinant Antibody
PurificationProtein A purified
AppearanceLiquid
FormulationPBS, Glycerol, BSA.
Concentration1mg/ml
Research BackgroundThe scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene. [provided by RefSeq].
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human Caveolin-1
Antigen Species
Human
Gene Name
CAV1
Gene ID
Protein Name
Caveolin-1
Uniprot ID
Function
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway.
Chemical Properties
Molecular WeightTheoretical: 20 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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