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JNJ-61432059

Name: JNJ-61432059
Brand: TargetMol
SKU: T15623
Price: 100 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15623Cas No. 2035814-50-5

JNJ-61432059 is an orally active and selective negative modulator of TARP γ-8 selective AMPAR (pIC50: 9.7).

JNJ-61432059

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Purity: 99.65%

Catalog No. T15623Cas No. 2035814-50-5

JNJ-61432059 is an orally active and selective negative modulator of TARP γ-8 selective AMPAR (pIC50: 9.7).

Pack Size	Price	Availability
1 mg	$100	In Stock
5 mg	$247	In Stock
10 mg	$353	In Stock
25 mg	$591	In Stock
50 mg	$787	In Stock
100 mg	$1,050	In Stock
200 mg	$1,420	In Stock
1 mL x 10 mM (in DMSO)	$272	In Stock

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Batch Information

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Purity:99.65%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	JNJ-61432059 is an orally active and selective negative modulator of TARP γ-8 selective AMPAR (pIC50: 9.7).
Targets&IC50	AMPAR:(pic50)9.7
In vivo	In mouse hippocampus, Exhibits time- and dose-dependent AMPAR/γ-8 receptor occupancy, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models.

Chemical Properties

Molecular Weight	443.47
Formula	C₂₅H₂₂FN₅O₂
Cas No.	2035814-50-5
Smiles	OC1CCN(CC1)c1nccc2c(c(nn12)-c1ccc(F)cc1)-c1ccc2NC(=O)Cc2c1
Relative Density.	1.49 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (146.57 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2549 mL	11.2747 mL	22.5494 mL	112.7472 mL
5 mM	0.4510 mL	2.2549 mL	4.5099 mL	22.5494 mL
10 mM	0.2255 mL	1.1275 mL	2.2549 mL	11.2747 mL
20 mM	0.1127 mL	0.5637 mL	1.1275 mL	5.6374 mL
50 mM	0.0451 mL	0.2255 mL	0.4510 mL	2.2549 mL
100 mM	0.0225 mL	0.1127 mL	0.2255 mL	1.1275 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc