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GW3965

Catalog No. T6310L CAS 405911-09-3

GW3965 is a potent, selective agonist of liver X receptor (LXR) with EC 50 s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively [1] [2] [3].

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GW3965, CAS 405911-09-3

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

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Description	GW3965 is a potent, selective agonist of liver X receptor (LXR) with EC 50 s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively [1] [2] [3].
In vitro	GW3965 effectively induces death in GBM cells in vitro, particularly in those expressing EGFRvIII. It enhances the expression of the cholesterol transporter gene ABCA1 and the E3 ubiquitin ligase IDOL, while decreasing LDLR levels. Furthermore, LXR ligands, including GW3965, can suppress both platelet aggregation and calcium mobilization induced by collagen or CRP. Although at lower concentrations (1 or 5 μM), GW3965 slightly inhibits fibrinogen binding and P-selectin exposure in platelets activated by 1 μg/mL CRP, higher doses of GW3965 (10 μM) or T0901317 (40 μM) significantly diminish fibrinogen and P-selectin levels on the platelet surface.
In vivo	GW3965 elevates neuroactive steroids in the spinal cord, cerebellum, and cerebral cortex of STZ-rats, not affecting the CNS in non-pathological subjects. It also enhances dihydroprogesterone levels and myelin basic protein expression in the spinal cord of diabetic rats [1]. At a dose of 40 mg/kg orally, GW3965 significantly upregulates ABCA1 expression and downregulates LDLR expression, which correlates with a 59% reduction in tumor growth and a substantial increase in GBM cell apoptosis by 25 times in vivo [2]. Additionally, administered intravenously at 2 mg/kg, GW3965 prolongs bleeding time and modulates platelet thrombus formation in vivo [3].

Molecular Weight	582.05
Formula	C33H31ClF3NO3
CAS No.	405911-09-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Citations

1. Yan C, Zheng L, Jiang S, et al.Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity.Cancer Cell.2023

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GW3965 405911-09-3 GW-3965 GW 3965 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.