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TCS PrP Inhibitor 13

Name: TCS PrP Inhibitor 13
Brand: TargetMol
SKU: T23450
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23450Cas No. 34320-83-7

Alias 5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One

TCS PrP Inhibitor 13 (5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One) is an antiprion agent inhibiting protease-resistant prion protein (PrP-res) accumulation.

TCS PrP Inhibitor 13

🥰Excellent

Purity: 99.7%

Catalog No. T23450Alias 5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-OneCas No. 34320-83-7

TCS PrP Inhibitor 13 (5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One) is an antiprion agent inhibiting protease-resistant prion protein (PrP-res) accumulation.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$32	In Stock	In Stock
10 mg	$53	In Stock	In Stock
25 mg	$107	In Stock	In Stock
50 mg	$167	In Stock	In Stock
100 mg	$257	In Stock	In Stock
200 mg	$366	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$34	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.7%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	TCS PrP Inhibitor 13 (5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One) is an antiprion agent inhibiting protease-resistant prion protein (PrP-res) accumulation.
Targets&IC50	PrPC:3 nM (in ScN2a and F3 cells)
In vitro	In Schwannoma cells, administration of 0-500 μM TCS PrP Inhibitor 13 reduces levels of total ERK1/2, pAKT, total FAK, Cyclin D1, PrPC and increases expression of cleaved caspase-3 significantly. TCS PrP Inhibitor 13 also significantly reduces the number of proliferating, Ki67-positive cells and total cell number in Schwannoma cells[2].
Synonyms	5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One

Chemical Properties

Molecular Weight	281.27
Formula	C₁₅H₁₁N₃O₃
Cas No.	34320-83-7
Smiles	[O-][N+](=O)c1ccc(cc1)C1=NN(C(=O)C1)c1ccccc1
Relative Density.	1.38g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 88 mg/mL (312.87 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (11.73 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5553 mL	17.7765 mL	35.5530 mL	177.7651 mL
5 mM	0.7111 mL	3.5553 mL	7.1106 mL	35.5530 mL
10 mM	0.3555 mL	1.7777 mL	3.5553 mL	17.7765 mL
20 mM	0.1778 mL	0.8888 mL	1.7777 mL	8.8883 mL
50 mM	0.0711 mL	0.3555 mL	0.7111 mL	3.5553 mL
100 mM	0.0356 mL	0.1778 mL	0.3555 mL	1.7777 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc