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Anti-CD27/TNFRSF7 Antibody-PE (4I709) is a PE-conjugated Rabbit antibody targeting CD27/TNFRSF7. Anti-CD27/TNFRSF7 Antibody-PE (4I709) can be used in FCM.
Description | Anti-CD27/TNFRSF7 Antibody-PE (4I709) is a PE-conjugated Rabbit antibody targeting CD27/TNFRSF7. Anti-CD27/TNFRSF7 Antibody-PE (4I709) can be used in FCM. |
Ig Type | Monoclonal Rabbit IgG |
Clone | 4I709 |
Reactivity | Mouse |
Verified Activity | Expression of CD27 on mouse splenocytes. BABL/c splenocytes were stained with PE-conjugated mAb R012. |
Application | FCM |
Recommended Dose | 1 μl/Test, 0.1 mg/ml |
Antibody Type | Monoclonal |
Host Species | Rabbit |
Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD27 / TNFRSF7 (rM CD27 / TNFRSF7; TMPY-01432; NP_001028298.1; Met 1-Arg 182) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
Purification | Protein A |
Appearance | Liquid |
Formulation | PBS solution containing 0.5% BSA and 0.09% sodium azide |
Research Background | CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a type I transmembrane glycoprotein of about 55 kDa existing as disulfide-linked homodimer, CD27 has been shown to play roles in lymphoid proliferation, differentiation, and apoptosis.It has an important role in the generation of T cell immunity and is an robust marker for normal memory B cells. It is a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B-cell differentiation, activation and immunoglobulin synthesis.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: ICC AntibodiesImmune Checkpoint Detection: IHC AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy |
Conjucates | PE |
Others Formats | Unconjugated/APC/PerCP/FITC |
Antibody Types Available | 5 |
Immunogen | Recombinant Mouse CD27 / TNFRSF7 protein (TMPY-01432) |
Antigen Species | Mouse |
Biology Area | Cancer Drug Targets |
Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
Transport | Shipping with blue ice. |
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