Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GSK3735967 is a selective, reversible, non-nucleoside inhibitor targeting DNMT1, demonstrating an IC50 value of 40 nM. It features a planar dicyanopyridine core designed to specifically interact with DNMT1-bound hemimethylated CpG dinucleotides. Additionally, GSK3735967 possesses three binding sites, with one uniquely capable of binding to histone H4K20me3 [1] [2].
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Description | GSK3735967 is a selective, reversible, non-nucleoside inhibitor targeting DNMT1, demonstrating an IC50 value of 40 nM. It features a planar dicyanopyridine core designed to specifically interact with DNMT1-bound hemimethylated CpG dinucleotides. Additionally, GSK3735967 possesses three binding sites, with one uniquely capable of binding to histone H4K20me3 [1] [2]. |
Molecular Weight | 477.62 |
Formula | C25H31N7OS |
CAS No. | 2170136-86-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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GSK3735967 2170136-86-2 inhibitor inhibit