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5β,6β-epoxycholestanol
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Catalog No. TCL-00012Cas No. 4025-59-6
5β,6β-Epoxycholestanol is an oxidative metabolite of cholesterol produced through radical and non-radical oxidation at the 5,6-double bond. It induces the release of lactate dehydrogenase (LDH) and apoptosis in differentiated macrophage U937 cells. This compound has been identified in human fatty streaks and advanced atherosclerotic lesions but is absent in normal aortic tissue.
5β,6β-epoxycholestanol
🥰Excellent
Catalog No. TCL-00012Cas No. 4025-59-6
5β,6β-Epoxycholestanol is an oxidative metabolite of cholesterol produced through radical and non-radical oxidation at the 5,6-double bond. It induces the release of lactate dehydrogenase (LDH) and apoptosis in differentiated macrophage U937 cells. This compound has been identified in human fatty streaks and advanced atherosclerotic lesions but is absent in normal aortic tissue.
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Chemical Properties
| Description | 5β,6β-Epoxycholestanol is an oxidative metabolite of cholesterol produced through radical and non-radical oxidation at the 5,6-double bond. It induces the release of lactate dehydrogenase (LDH) and apoptosis in differentiated macrophage U937 cells. This compound has been identified in human fatty streaks and advanced atherosclerotic lesions but is absent in normal aortic tissue. |
| Molecular Weight | 402.6529 |
| Formula | C27H46O2 |
| Cas No. | 4025-59-6 |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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