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AFM24
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Catalog No. T9901A-513 Copy Product Info
Purity: 95%
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AFM24 is a bispecific antibody with a TandAb structure expressed in CHO cells, simultaneously targeting the Epidermal Growth Factor Receptor (EGFR) and FcγRIIIA (CD16A). It consists of a huIgG1-scFv heavy chain and a λ light chain, with a predicted molecular weight of 196.34 kDa. As a novel innate immune cell engager, AFM24 binds with high affinity to CD16A on NK cells and macrophages, directing these effector cells to eliminate EGFR-positive tumor cells. Its mechanism primarily leverages enhanced antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP) to overcome limitations of conventional anti-EGFR therapies.
AFM24
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $290 | - | In Stock | |
| 5 mg | $788 | - | In Stock | |
| 10 mg | $1,230 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:95%
Appearance:Liquid
Color:Transparent
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Product Introduction
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Chemical Properties
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| Description | AFM24 is a bispecific antibody with a TandAb structure expressed in CHO cells, simultaneously targeting the Epidermal Growth Factor Receptor (EGFR) and FcγRIIIA (CD16A). It consists of a huIgG1-scFv heavy chain and a λ light chain, with a predicted molecular weight of 196.34 kDa. As a novel innate immune cell engager, AFM24 binds with high affinity to CD16A on NK cells and macrophages, directing these effector cells to eliminate EGFR-positive tumor cells. Its mechanism primarily leverages enhanced antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP) to overcome limitations of conventional anti-EGFR therapies. |
| In vitro | AFM24 binds with high affinity to EGFR and CD16A, inducing potent NK cell-mediated cytotoxicity against EGFR-positive tumor cells. Its activity is independent of EGFR signaling, overcoming resistance driven by KRAS/BRAF mutations. It also promotes macrophage-mediated ADCP [1]. |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal, Bispecific |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | CD16a & EGFR |
| Molecular Weight | 150 kDa |
| Isotype | IgG1 |
| Storage | Store at low temperature Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: AFM24 in vitro | AFM24 molecular weight
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