Powder: -20°C for 3 years | In solvent: -80°C for 1 year
FTase-IN-1 (compound 17a) is a highly effective inhibitor of fanesyl transferase (FTase), exhibiting a remarkable IC50 value of 0.35 μM. This compound demonstrates significant cytotoxicity potential and exhibits powerful antitumor activity [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | FTase-IN-1 (compound 17a) is a highly effective inhibitor of fanesyl transferase (FTase), exhibiting a remarkable IC50 value of 0.35 μM. This compound demonstrates significant cytotoxicity potential and exhibits powerful antitumor activity [1]. |
In vitro | FTase-IN-1 (compound 17a) at a concentration of 10 μM over 48 hours, serves as an inhibitor of farnesyl transferase (FTase) and demonstrates significant inhibition of the NCI-60 cell proliferation in vitro [1]. Additionally, this compound effectively halts the growth of various cancer cell lines, achieving half-maximal growth inhibition (GI50) values ranging between 1.8 to 6.5 nM [1]. Through Cell Viability Assays [1], it has been shown to markedly inhibit cell growth across a diverse set of cancer types, including lung (NCI-H522), colon (COLO-205 and HT29), glioblastoma (SF-539), melanoma (MDA-MB-435), ovarian (OVCAR-3), and renal (A498) cancers, underlining its potent antitumor activities at the administered concentration and incubation period. |
Molecular Weight | 384.45 |
Formula | C23H16N2O2S |
CAS No. | 2490538-41-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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FTase-IN-1 2490538-41-3 inhibitor inhibit