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FSC231
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Catalog No. T86471Cas No. 1215849-96-9
FSC231 is a protein kinase Cα-interacting protein 1 (PICK1) inhibitor with analgesic activity, alleviating paclitaxel-induced neuropathic pain by inhibiting PICK1 and modulating related factors, activating GSK-3β and ERK1/2.
FSC231
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Purity: 99.66%
Catalog No. T86471Cas No. 1215849-96-9
FSC231 is a protein kinase Cα-interacting protein 1 (PICK1) inhibitor with analgesic activity, alleviating paclitaxel-induced neuropathic pain by inhibiting PICK1 and modulating related factors, activating GSK-3β and ERK1/2.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $48 | In Stock | In Stock | |
| 5 mg | $113 | In Stock | In Stock | |
| 10 mg | $185 | In Stock | In Stock | |
| 25 mg | $363 | In Stock | In Stock | |
| 50 mg | $579 | In Stock | In Stock | |
| 100 mg | $892 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $126 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.66%
Appearance:Solid
Color:White
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Product Introduction
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| Description | FSC231 is a protein kinase Cα-interacting protein 1 (PICK1) inhibitor with analgesic activity, alleviating paclitaxel-induced neuropathic pain by inhibiting PICK1 and modulating related factors, activating GSK-3β and ERK1/2. |
| In vitro | FSC231 (50 μM) treatment inhibits COS7 cells and blocks the interaction between GluR2 and PICK1 in cells [2]. Methods: FSC231 (50 μM) was used to treat CA1 neurons in acute slices to observe its effect on LTP expression in neurons. Results: FSC231 can significantly reduce LTP expression. [2] |
| In vivo | Methods: The expression level of PICK1 in rat dorsal root ganglia (DRG) was altered by vector plasmids, and the effect of PICK1 on paclitaxel (PTL)-induced neuropathic pain in rats was observed in combination with FSC231 (78.40 μg/kg, intraperitoneal injection). The possible molecular mechanisms were explored by quantitative real-time polymerase chain reaction (qRT-PCR), Western Blot and co-immunoprecipitation (Co-IP) techniques. Results: PTL treatment significantly reduced the mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) of rats, promoted DRG inflammation and the release of substance P (SP), stimulated PICK1 expression, reduced the level of α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor 2 (AMPAR, GluA2), and increased the phosphorylation of rat glycogen synthase kinase-3β (GSK-3β) and extracellular regulated protein kinase 1/2 (ERK1/2), while FSC231 treatment could alleviate the above effects induced by PTL and alleviate the effects of PTL-induced neuropathic pain in rats. In addition, PICK1 overexpression could counteract the decreased PICK1 level, increased GluA2 level, and decreased phosphorylation of GSK-3β and ERK1/2 caused by FSC231 treatment. The results of Co-IP confirmed the interaction between PICK1 and GluA2. Both FSC231 treatment and PICK1 silencing improved PTL-induced MWT reduction, TWL shortening, inflammation, SP release, and related gene expression changes, with cumulative effects.[1] |
| Molecular Weight | 313.14 |
| Formula | C13H10Cl2N2O3 |
| Cas No. | 1215849-96-9 |
| Smiles | C(=C(/C(NC(OCC)=O)=O)\C#N)\C1=CC(Cl)=C(Cl)C=C1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (127.74 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+90% Corn Oil: 2 mg/mL (6.39 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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